{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:09:10Z","timestamp":1756634950034,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"publisher","award":["DFF-3101-00393B"],"award-info":[{"award-number":["DFF-3101-00393B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus University Research Foundation","doi-asserted-by":"publisher","award":["AUFF-E-2022-9-25"],"award-info":[{"award-number":["AUFF-E-2022-9-25"]}],"id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Heligmosomoides polygyrus coinfection is reported to have protective antiviral effects against pulmonary viral infections. To investigate a potential underlying mechanism, we infected C57BL\/6 mice with H. polygyrus larvae for 2 weeks. Bone marrow (BM)-derived plasmacytoid dendritic cells (pDCs) were generated and stimulated with Toll-like receptor agonists. We found increased expression of type 1 interferon genes (Ifn\u03b11, Ifn\u03b14, Ifn\u03b21, Mx1, Isg15), increased TNF, IL-6, IL-10 secretion, and higher expression of antigen presentation markers in BM-derived-pDCs from infected compared to naive control mice. Our findings may partly explain the mechanism of the antiviral protection previously reported in acute helminth infections.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf009","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T15:12:08Z","timestamp":1736003528000},"page":"230-235","source":"Crossref","is-referenced-by-count":1,"title":["Helminth Infection Induces Innate Immune Priming in Plasmacytoid Dendritic Cells"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-5657","authenticated-orcid":false,"given":"Lamin B","family":"Cham","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Infectious Diseases, College of Medicine and Health Sciences, Arabian Gulf University , Manama ,","place":["Bahrain"]},{"name":"Department of Clinical Medicine, Aarhus University , Aarhus ,","place":["Denmark"]},{"name":"Department of Infectious Diseases, Aarhus University Hospital , Aarhus 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