{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:40:00Z","timestamp":1766050800651,"version":"3.41.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA260513"],"award-info":[{"award-number":["U01CA260513"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"United States Veterans Administration","award":["COVID19-8900-05"],"award-info":[{"award-number":["COVID19-8900-05"]}]},{"DOI":"10.13039\/100012729","name":"Clinical and Translational Science Collaborative of Cleveland","doi-asserted-by":"publisher","award":["UM1TR002548"],"award-info":[{"award-number":["UM1TR002548"]}],"id":[{"id":"10.13039\/100012729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We sought to identify the immunobiologic underpinnings of cardiac involvement as a postacute sequela of coronavirus disease 2019 (COVID-19) by comparing acute and convalescent populations. For the latter, an integrated analysis of cytokine levels, cardiac magnetic resonance imaging, and cardiopulmonary exercise capacity was performed. Unlike acute cardiac injury, which was associated with heightened tumor necrosis factor alpha (TNF-\u03b1) but not interleukin 18 (IL-18), convalescent myocardial inflammation\/edema correlated with IL-18 but not TNF-\u03b1. Thus, inflammation is not a monolith in relation to cardiac involvement in the setting of COVID-19. Instead, convalescent cardiac involvement may emerge from mechanisms distinct from acute injury, and appropriately targeted therapies may prevent postacute sequalae of COVID-19.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf045","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T20:22:15Z","timestamp":1738009335000},"page":"e918-e920","source":"Crossref","is-referenced-by-count":1,"title":["Distinct Cytokine Patterns Identify Acute and Convalescent Myocardial Involvement After Coronavirus Disease 2019: A Multicohort Biomarker Study"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-3986","authenticated-orcid":false,"given":"David A","family":"Zidar","sequence":"first","affiliation":[{"name":"Departments of Pathology and Medicine, Case Western Reserve University School of Medicine"},{"name":"Department of Medicine, University Hospitals Cleveland Medical Center"},{"name":"Department of Pathology, Louis Stokes Cleveland Veterans Affairs Medical Center , Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace A","family":"McComsey","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Medicine, Case Western Reserve University School of Medicine"},{"name":"Department of Medicine, University Hospitals Cleveland Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-5976","authenticated-orcid":false,"given":"Donald D","family":"Anthony","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Medicine, Case Western Reserve University School of Medicine"},{"name":"Department of Pathology, Louis Stokes Cleveland Veterans Affairs Medical Center , Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"McDaniel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louis Stokes Cleveland Veterans Affairs Medical Center , Cleveland"},{"name":"School of Health Sciences, Kent State University , Kent"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy A","family":"Chan","sequence":"additional","affiliation":[{"name":"Global Center for Immunotherapy and Immuno-Oncology, Cleveland Clinic Lerner College of Medicine , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadeer G","family":"Al-Kindi","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Medicine, Case Western Reserve University School of Medicine"},{"name":"Department of Medicine, University Hospitals Cleveland Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"2025060208122737400_jiaf045-B1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.trsl.2021.11.005","article-title":"COVID-lateral damage: cardiovascular manifestations of SARS-CoV-2 infection","volume":"241","author":"Al-Kindi","year":"2022","journal-title":"Transl Res"},{"key":"2025060208122737400_jiaf045-B2","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1161\/CIRCRESAHA.122.322228","article-title":"A post-pandemic Enigma: the cardiovascular impact of post-acute sequelae of SARS-CoV-2","volume":"132","author":"Singh","year":"2023","journal-title":"Circ Res"},{"key":"2025060208122737400_jiaf045-B3","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jamacardio.2020.3557","article-title":"Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19)","volume":"5","author":"Puntmann","year":"2020","journal-title":"JAMA Cardiol"},{"key":"2025060208122737400_jiaf045-B4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jmri.27534","article-title":"Cardiac T1 and T2 mapping showed myocardial involvement in recovered COVID-19 patients initially considered devoid of 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