{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:24:14Z","timestamp":1754162654056,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100019533","name":"Moderna","doi-asserted-by":"publisher","award":["VAL 2023-524\/0"],"award-info":[{"award-number":["VAL 2023-524\/0"]}],"id":[{"id":"10.13039\/100019533","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Respiratory syncytial virus (RSV) can cause severe infections in elderly individuals. Nirsevimab is a novel prophylactic monoclonal antibody, widely used in infants in France during the 2023\u20132024 season. It may select for resistant RSV variants that, if transmitted in the community, could compromise vaccine efficacy in the elderly. In this study, we analyzed RSV full-length genomes (68% RSV-A, 32% RSV-B) from 125 patients aged &amp;gt;60\u2005years during the 2023\u20132024 season. Genetic diversity of RSV-F site \u00d8 was low, with no resistance-associated substitutions (RASs) detected. While no RASs were identified, ongoing monitoring is essential to prevent the emergence of resistant variants that could affect vaccine efficacy in the elderly.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf062","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T23:19:32Z","timestamp":1738279172000},"page":"199-202","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Characterization of Respiratory Syncytial Virus Infections in Elderly Patients During the 2023\u20132024 Season in the Era of Nirsevimab Introduction"],"prefix":"10.1093","volume":"232","author":[{"given":"Amandine","family":"Caillault","sequence":"first","affiliation":[{"name":"Department of Virology, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"},{"name":"Department of Virology, Universit\u00e9 Paris-Est-Cr\u00e9teil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Softic","sequence":"additional","affiliation":[{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-2110","authenticated-orcid":false,"given":"Pierre","family":"Bay","sequence":"additional","affiliation":[{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"},{"name":"Department of Intensive Care, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Groupe de Recherche CARMAC, Universit\u00e9 Paris-Est-Cr\u00e9teil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Ly","sequence":"additional","affiliation":[{"name":"Department of Virology, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Soulier","sequence":"additional","affiliation":[{"name":"Department of Virology, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Melica","sequence":"additional","affiliation":[{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"},{"name":"Department of Virology, Universit\u00e9 Paris-Est-Cr\u00e9teil"},{"name":"Department of Infectious Diseases and Clinical Immunology, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Virology, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"},{"name":"Department of Virology, Universit\u00e9 Paris-Est-Cr\u00e9teil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-4320","authenticated-orcid":false,"given":"Nicolas","family":"de Prost","sequence":"additional","affiliation":[{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"},{"name":"Department of Intensive Care, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Groupe de Recherche CARMAC, Universit\u00e9 Paris-Est-Cr\u00e9teil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Pawlotsky","sequence":"additional","affiliation":[{"name":"Department of Virology, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"},{"name":"Department of Virology, Universit\u00e9 Paris-Est-Cr\u00e9teil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-5467","authenticated-orcid":false,"given":"Slim","family":"Fourati","sequence":"additional","affiliation":[{"name":"Department of Virology, H\u00f4pital Henri Mondor, Assistance Publique\u2013H\u00f4pitaux de Paris"},{"name":"Viruses, Hepatology, and Cancer Research Team, Inserm U955, Institut Mondor de Recherche Biom\u00e9dicale"},{"name":"Department of Virology, Universit\u00e9 Paris-Est-Cr\u00e9teil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"2025073007424030900_jiaf062-B1","doi-asserted-by":"crossref","first-page":"ofad131","DOI":"10.1093\/ofid\/ofad131","article-title":"Epidemiology and characteristics of respiratory syncytial virus pneumonia in critically ill adults","volume":"10","author":"Kim","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"2025073007424030900_jiaf062-B2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2165\/00002512-200522070-00004","article-title":"Respiratory syncytial virus infection in elderly adults","volume":"22","author":"Falsey","year":"2005","journal-title":"Drugs Aging"},{"key":"2025073007424030900_jiaf062-B3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41579-023-00919-w","article-title":"Respiratory syncytial virus infection and novel interventions","volume":"21","author":"Langedijk","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"2025073007424030900_jiaf062-B4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40265-022-01829-6","article-title":"Nirsevimab: first approval","volume":"83","author":"Keam","year":"2023","journal-title":"Drugs"},{"key":"2025073007424030900_jiaf062-B5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1056\/NEJMoa2314885","article-title":"Nirsevimab and hospitalization for RSV bronchiolitis","volume":"391","author":"Assad","year":"2024","journal-title":"N Engl J Med"},{"key":"2025073007424030900_jiaf062-B6","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1038\/s41467-023-40057-8","article-title":"Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials","volume":"14","author":"Ahani","year":"2023","journal-title":"Nat Commun"},{"key":"2025073007424030900_jiaf062-B7","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.immuni.2021.03.004","article-title":"Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses","volume":"54","author":"Mukhamedova","year":"2021","journal-title":"Immunity"},{"key":"2025073007424030900_jiaf062-B8","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.3201\/eid3008.240209","article-title":"Standardized phylogenetic classification of human respiratory syncytial virus below the subgroup level","volume":"30","author":"Goya","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"2025073007424030900_jiaf062-B9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.coi.2015.04.005","article-title":"Novel antigens for RSV vaccines","volume":"35","author":"Graham","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"2025073007424030900_jiaf062-B10","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00570-X","article-title":"Genotypic and phenotypic characterisation of respiratory syncytial virus after nirsevimab breakthrough infections: a large, multicentre, observational, real-world study [manuscript published online ahead of print 14 October 2024]","author":"Fourati","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2025073007424030900_jiaf062-B11","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S1473-3099(23)00062-2","article-title":"Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data","volume":"23","author":"Wilkins","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"Suppl 2","key":"2025073007424030900_jiaf062-B12","doi-asserted-by":"crossref","first-page":"ofad500.2253","DOI":"10.1093\/ofid\/ofad500.2253","article-title":"2641. Nirsevimab binding-site conservation in RSV F protein between 2015 and 2022: the US OUTSMART-RSV surveillance study","volume":"10","author":"Morehouse","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"2025073007424030900_jiaf062-B13","doi-asserted-by":"crossref","first-page":"105759","DOI":"10.1016\/j.jcv.2024.105759","article-title":"The molecular epidemiology of respiratory syncytial virus in Ontario, Canada from 2022\u20132024 using a custom whole genome sequencing assay and analytics package","volume":"176","author":"Wong","year":"2025","journal-title":"J Clin Virol"},{"key":"2025073007424030900_jiaf062-B14","doi-asserted-by":"crossref","first-page":"16055","DOI":"10.3390\/ijms242216055","article-title":"The modification of the Illumina CovidSeq workflow for RSV genomic surveillance: the genetic variability of RSV during the 2022\u20132023 season in northwest Spain","volume":"24","author":"Davina-Nunez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025073007424030900_jiaf062-B15","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/infdis\/jiae636","article-title":"Amino acid substitutions in the fusion protein of respiratory syncytial virus in Fukushima, Japan during 2008\u20132023 and their effects","volume":"231","author":"Okabe","year":"2025","journal-title":"J Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiaf062\/61738469\/jiaf062.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/232\/1\/199\/61738469\/jiaf062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/232\/1\/199\/61738469\/jiaf062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:42:51Z","timestamp":1753875771000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/232\/1\/199\/7997040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,3]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,3]]},"published-print":{"date-parts":[[2025,7,30]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiaf062","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"type":"print","value":"0022-1899"},{"type":"electronic","value":"1537-6613"}],"subject":[],"published-other":{"date-parts":[[2025,7,15]]},"published":{"date-parts":[[2025,2,3]]}}}