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Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A\u2212) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33\u20134.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf080","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:48:31Z","timestamp":1739346511000},"page":"127-132","source":"Crossref","is-referenced-by-count":0,"title":["Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-6526","authenticated-orcid":false,"given":"Ruth","family":"Namazzi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Makerere University College of Health Sciences , Kampala ,","place":["Uganda"]},{"name":"Global Health Uganda , Kampala 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