{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:34:02Z","timestamp":1775594042367,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UC7AI094660"],"award-info":[{"award-number":["UC7AI094660"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chapare virus (CHAPV) is an emerging arenavirus first discovered in Bolivia. Clinical cases have a high case-fatality rate and a concerning capacity for person-to-person spread. Animal models of Chapare hemorrhagic fever are needed to study pathogenesis and development of medical counter measures. Here, we present a narrowly focused study describing lethal infection of strain 13 guinea pigs with CHAPV. Animals challenged with CHAPV had progressive weight loss, lymphocytopenia, neutropenia, thrombocytopenia, hepatitis, vascular leakage, and gastrointestinal hemorrhage, resulting in uniform lethality between 7 and 16 days following challenge. This work lays the foundation for development of a small animal model of CHAPV infection.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf081","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:01:21Z","timestamp":1740124881000},"page":"e867-e872","source":"Crossref","is-referenced-by-count":5,"title":["Natural History of Chapare Virus Infection in Strain 13 Guinea Pigs"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3630-0588","authenticated-orcid":false,"given":"Dylan M","family":"Johnson","sequence":"first","affiliation":[{"name":"Galveston National Laboratory , Galveston, Texas ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla A","family":"Fenton","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory , Galveston, Texas ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Dobias","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory , Galveston, Texas ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-1877","authenticated-orcid":false,"given":"Thomas W","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory , Galveston, Texas ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-1522","authenticated-orcid":false,"given":"Robert W","family":"Cross","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory , Galveston, Texas ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"2025060208123583900_jiaf081-B1","doi-asserted-by":"crossref","first-page":"e1000047","DOI":"10.1371\/journal.ppat.1000047","article-title":"Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia","volume":"4","author":"Delgado","year":"2008","journal-title":"PLoS Pathog"},{"key":"2025060208123583900_jiaf081-B2","doi-asserted-by":"crossref","first-page":"101589","DOI":"10.1016\/j.tmaid.2020.101589","article-title":"Clinical features of fatal cases of Chapare virus hemorrhagic fever originating from rural La Paz, Bolivia, 2019: a cluster analysis","volume":"36","author":"Escalera-Antezana","year":"2020","journal-title":"Travel Med Infect Dis"},{"key":"2025060208123583900_jiaf081-B3","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1056\/NEJMoa2110339","article-title":"Chapare hemorrhagic fever and virus detection in rodents in Bolivia in 2019","volume":"386","author":"Loayza Mafayle","year":"2022","journal-title":"N Engl J Med"},{"key":"2025060208123583900_jiaf081-B4","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1644\/1545-1542(2001)082<1080:CSOSSO>2.0.CO;2","article-title":"Chromosome studies of seven species of Oligoryzomys (Rodentia: Sigmodontinae) from Brazil","volume":"82","author":"Andrades-Miranda","year":"2001","journal-title":"J Mammal"},{"key":"2025060208123583900_jiaf081-B5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1089\/vbz.2009.0115","article-title":"Geographical range of Rio Mamore virus (family Bunyaviridae, genus Hantavirus) in association with the small-eared pygmy rice rat (Oligoryzomys microtis)","volume":"10","author":"Richter","year":"2010","journal-title":"Vector Borne Zoonotic Dis"},{"key":"2025060208123583900_jiaf081-B6","first-page":"793257","article-title":"Animal models for the study of rodent-borne hemorrhagic fever viruses: arenaviruses and hantaviruses","volume":"2015","author":"Golden","year":"2015","journal-title":"BioMed Res Int"},{"key":"2025060208123583900_jiaf081-B7","doi-asserted-by":"crossref","first-page":"1172792","DOI":"10.3389\/fimmu.2023.1172792","article-title":"The roles of XJ13 and XJ44-specific mutations within the Candid# 1 GPC in Junin virus attenuation","volume":"14","author":"Manning","year":"2023","journal-title":"Front Immunol"},{"key":"2025060208123583900_jiaf081-B8","doi-asserted-by":"crossref","first-page":"e3725","DOI":"10.1371\/journal.pone.0003725","article-title":"Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin","volume":"3","author":"Gowen","year":"2008","journal-title":"PLoS One"},{"key":"2025060208123583900_jiaf081-B9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41541-021-00361-0","article-title":"Single dose rVSV\u0394G-JUNVGP vaccine protects Guinea pigs against lethal Junin virus challenge","volume":"6","author":"Sorvillo","year":"2021","journal-title":"NPJ Vaccines"},{"key":"2025060208123583900_jiaf081-B10","doi-asserted-by":"crossref","first-page":"e00428-19","DOI":"10.1128\/mSphere.00428-19","article-title":"Lethal infection of Lassa virus isolated from a human clinical sample in outbred Guinea pigs without adaptation","volume":"4","author":"Maruyama","year":"2019","journal-title":"MSphere"},{"key":"2025060208123583900_jiaf081-B11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/iai.37.2.771-778.1982","article-title":"Pathogenesis of Lassa virus infection in Guinea pigs","volume":"37","author":"Jahrling","year":"1982","journal-title":"Infect Immun"},{"key":"2025060208123583900_jiaf081-B12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1128\/iai.34.2.323-327.1981","article-title":"Cell-mediated immunity and lymphocyte populations in experimental Argentine hemorrhagic fever (Junin virus)","volume":"34","author":"Carballal","year":"1981","journal-title":"Infect Immun"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiaf081\/62040548\/jiaf081.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/5\/e867\/62040548\/jiaf081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/231\/5\/e867\/62040548\/jiaf081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:12:43Z","timestamp":1748866363000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/231\/5\/e867\/8029142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,2,21]]},"published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiaf081","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5,15]]},"published":{"date-parts":[[2025,2,21]]}}}