{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:46:38Z","timestamp":1778946398331,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"publisher","award":["PI20\/01457"],"award-info":[{"award-number":["PI20\/01457"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Liver stiffness (LS) is not reduced in 10%\u201330% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters associated with cellular aging measured at the DAA initiation date are related to LS reduction upon achieving SVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a prospective cohort study (GEHEP-011) we measured several parameters associated with cellular aging, such as telomere attrition, mitochondrial alterations, and soluble biomarkers associated with senescence-associated secretory phenotype at the DAA initiation date, and examined their associations with a significant (\u226520%) LS decrease at the SVR time point.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 175 individuals were included in this study. In 101 (57.7%) patients, the LS reduction was \u226520% at SVR. In the multivariate analysis adjusted for sex, age, CXCL10, hsPCR, and CCL11 levels, greater relative telomere length (RTL) emerged as the sole variable independently associated with a significant LS decrease in SVR (1.102; 95% confidence interval, 1.001\u20131.1214; P = .047). Furthermore, changes in LS, including significant decrease, decrease &amp;lt;20%, or increase, were congruently associated with RTL (P = .011).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Greater RTL was independently associated with a significant LS reduction in SVR. Thus, increased cellular aging may be responsible for the absence of liver regeneration after HCV eradication. Further studies are required to assess the long-term effects of cellular aging after SVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT04460157.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf087","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T18:14:31Z","timestamp":1739988871000},"page":"e846-e852","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-8417","authenticated-orcid":false,"given":"Alejandro","family":"Gonzalez-Serna","sequence":"first","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]},{"name":"Facultad de Farmacia, Departamento de Fisiolog\u00eda, Universidad de Sevilla , Sevilla ,","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla , Sevilla ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-0237","authenticated-orcid":false,"given":"Ana\u00efs","family":"Corma-Gomez","sequence":"additional","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla , Sevilla ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-0072","authenticated-orcid":false,"given":"Mercedes","family":"Cano","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia, Departamento de Fisiolog\u00eda, Universidad de Sevilla , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-4191","authenticated-orcid":false,"given":"Ricardo","family":"Rubio-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Servicio de An\u00e1lisis Cl\u00ednicos, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-1054","authenticated-orcid":false,"given":"Carmen","family":"Mart\u00edn-Sierra","sequence":"additional","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla , Sevilla ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-4745","authenticated-orcid":false,"given":"Jesica","family":"Mart\u00edn-Carmona","sequence":"additional","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Pineda","sequence":"additional","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]},{"name":"Departamento de Medicina, Universidad de Sevilla , Sevilla ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-7429","authenticated-orcid":false,"given":"Luis Miguel","family":"Real","sequence":"additional","affiliation":[{"name":"Grupo Virolog\u00eda e ITS, Hospital Universitario Virgen de Valme , Sevilla ,","place":["Spain"]},{"name":"Instituto de Biomedicina de Sevilla , Sevilla ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas ,","place":["Spain"]},{"name":"Departamento de Bioqu\u00edmica M\u00e9dica, Biolog\u00eda Molecular e Inmunolog\u00eda, Universidad de Sevilla , Sevilla 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