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Notably, the transfer of these cells accelerates sepsis-induced lung injury and death in mice. Furthermore, the CD11c+ B cells were induced by the triggering receptor expressed on myeloid cells 2 (TREM2) signal, which promotes their generation via the interferon regulatory factor 4 (IRF4) pathway. Moreover, TREM2 directly participates in sepsis regulation mediated by CD11c+ B cells. This study reveals the proinflammatory role of CD11c+ B cells in sepsis and identifies TREM2 as a contributing factor in CD11c+ B-cell\u2013mediated inflammatory injury during sepsis.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf112","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:07:06Z","timestamp":1744286826000},"source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory CD11c+ B Cells Induced by the TREM2 Signal Accelerate Sepsis Development"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1499-0098","authenticated-orcid":false,"given":"Siqi","family":"Ming","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University , Qingyuan, Guangdong ,","place":["China"]},{"name":"Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital , Zhuhai, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Qingyuan Hospital of Traditional Chinese Medicine , Qingyuan, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital , Zhuhai, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University , Qingyuan, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofeng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University , Qingyuan, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University , Qingyuan, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-8760","authenticated-orcid":false,"given":"Yongjian","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University , Zhuhai, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4829-8390","authenticated-orcid":false,"given":"Xi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, 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