{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:25:28Z","timestamp":1793215528124,"version":"4.5.0"},"reference-count":120,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Influenza antivirals play an important role in the prevention and control of influenza. We reviewed data on the effectiveness of influenza antivirals for reducing influenza transmission. We found that antiviral prophylaxis, whether given pre- or postexposure, has been shown to reduce the risk of symptomatic influenza in a variety of settings and populations. During pandemic responses, antiviral prophylaxis could play an important role, as demonstrated by the use of amantadine in the 1968\u20131969 influenza A(H3N2) pandemic and oseltamivir during the 2009\u20132010 influenza A(H1N1)pdm09 pandemic. Antiviral treatment reduces symptom severity, prevents complications, and can reduce onward transmission of infection. However, resistance, accessibility, and timing pose challenges. Future research directions include innovative therapies and combination treatments. Continued research and stewardship are crucial to optimize antiviral impact.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf116","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T02:26:55Z","timestamp":1760668015000},"page":"S215-S226","source":"Crossref","is-referenced-by-count":10,"title":["Use of Influenza Antivirals to Prevent Transmission"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-7154","authenticated-orcid":false,"given":"Benjamin J","family":"Cowling","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region ,","place":["China"]},{"name":"Laboratory of Data Discovery for Health Limited, Hong Kong Science and Technology Park , New Territories, Hong Kong Special Administrative Region ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4826-806X","authenticated-orcid":false,"given":"Yun","family":"Lin","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-4231","authenticated-orcid":false,"given":"Hideyuki","family":"Ikematsu","sequence":"additional","affiliation":[{"name":"Ricerca Clinica , Fukuoka ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"2025101622264788000_jiaf116-B1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.144.3620.862","article-title":"Antiviral activity of 1-adamantanamine (amantadine)","volume":"144","author":"Davies","year":"1964","journal-title":"Science"},{"key":"2025101622264788000_jiaf116-B2","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1001\/jama.1970.03170070019004","article-title":"Evaluation of therapeutic efficacy of amantadine in patients with naturally occurring A2 influenza","volume":"211","author":"Togo","year":"1970","journal-title":"JAMA"},{"key":"2025101622264788000_jiaf116-B3","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/clinids\/3.3.408","article-title":"Study of rimantadine in the USSR: a review of the 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