{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:17Z","timestamp":1787008997146,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primate T-cell leukemia virus type 1 (PTLV-1), classified into the genus Deltaretrovirus, persists in infected primates and can lead to adult T-cell leukemia and inflammatory diseases. Unlike hepatitis viruses, it remains unclear whether PTLV-1 could cause occult infection, a rare latent infection status characterized by detectable provirus without accompanying antibody responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal study was conducted to characterize mother-to-child transmission of simian T-cell leukemia virus type 1 (STLV-1) in Japanese macaques (JMs). Stored blood samples obtained from STLV-1\u2013infected JM mothers and their offspring were analyzed for proviral loads, antiviral antibody titers, proviral DNA sequencing, transcriptional capability, and clonality of the infected cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One JM infant was found to be positive for proviral DNA without detectable anti-STLV-1 antibodies. The seronegative infection persisted for at least 5 years, despite positive antibody responses to other viruses that are widespread in JMs. Further analyses of the infant's blood demonstrated that (1) the provirus had no defective mutations, (2) tax messenger RNA expression could be induced by in vitro culture, and (3) substantial numbers of heterogeneous clones of STLV-1\u2013infected cells were undergoing sequential turnover. In an additional retrospective study of a large JM cohort, 3 of 38 offspring of STLV-1\u2013infected mothers were found to be persistently infected with STLV-1 without seroconversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that maternal STLV-1 transmission can occasionally persist for years without seroconversion. This represents the first discovery of occult infection in the genus Deltaretrovirus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf120","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T23:23:01Z","timestamp":1741044181000},"page":"510-518","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Occult Simian T-Cell Leukemia Virus Type 1 Infection in Japanese Macaques"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5447-9462","authenticated-orcid":false,"given":"Maureen","family":"Kidiga","sequence":"first","affiliation":[{"name":"Center for the Evolutionary Origins of Human Behavior, Kyoto University , Inuyama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6048-7663","authenticated-orcid":false,"given":"Megumi","family":"Murata","sequence":"additional","affiliation":[{"name":"Center for the 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