{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:47:17Z","timestamp":1755226037447,"version":"3.43.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI116706","R01 AI177002","R01 AI176999","T32 GM148382","UL1 TR002529"],"award-info":[{"award-number":["R01 AI116706","R01 AI177002","R01 AI176999","T32 GM148382","UL1 TR002529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We investigated the relationship between Chlamydia trachomatis load and anti-chlamydial antibody using first-catch urine from 108 men with nongonococcal urethritis. Men who reported prior chlamydia had elevated anti-chlamydial IgA and lower loads, but load and antibody were not correlated. Load positively correlated with anti-chlamydial IgA only in men who did not self-report prior chlamydia and with anti-chlamydial IgG regardless of infection history. Overall, we document genotype-specific differences in C. trachomatis load, clarify that partial immunity associated with repeat infections is not antibody mediated, and demonstrate a method to monitor humoral immune responses to C. trachomatis in men using noninvasively collected urine.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf139","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:54:47Z","timestamp":1742198087000},"source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive Monitoring of Humoral Immune Responses in Men With Acute <i>Chlamydia trachomatis<\/i> Urethral Infection Using First-Catch Urine"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-8284","authenticated-orcid":false,"given":"John D","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7915-4437","authenticated-orcid":false,"given":"Caleb M","family":"Ardizzone","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]},{"name":"Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-2566","authenticated-orcid":false,"given":"Stephen J","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]},{"name":"Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-0126","authenticated-orcid":false,"given":"Aaron C","family":"Ermel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3134-3869","authenticated-orcid":false,"given":"Waleed M","family":"Alrebdi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-1425","authenticated-orcid":false,"given":"Teresa A","family":"Batteiger","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-4060","authenticated-orcid":false,"given":"Evelyn","family":"Toh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-7208","authenticated-orcid":false,"given":"David E","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"2025040207473954000_jiaf139-B1","first-page":"1","volume-title":"Intracellular pathogens I: Chlamydiales","author":"Batteiger","year":"2012"},{"key":"2025040207473954000_jiaf139-B2","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3389\/fimmu.2018.01981","article-title":"An adaptive Chlamydia trachomatis-specific IFN-\u03b3-producing CD4+ T cell response is associated with protection against Chlamydia reinfection in women","volume":"9","author":"Bakshi","year":"2018","journal-title":"Front Immunol"},{"key":"2025040207473954000_jiaf139-B3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/infdis\/jiae092","article-title":"Interferon-\u03b3 responses to Chlamydia trachomatis vaccine candidate proteins in women with different chlamydia 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