{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:51:16Z","timestamp":1789764676097,"version":"4.0.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antifungal susceptibility testing among 1740 Candida parapsilosis blood isolates submitted to a United States reference laboratory (2015\u20132024) revealed a significant increase in fluconazole resistance from 8.2% to 20.3% (odds ratio [OR] per year, 1.13 [95% confidence interval {CI}, 1.06\u20131.20]; P &amp;lt; .001), with notable acceleration since 2021. Voriconazole resistance remained stable over this period. Micafungin resistance was rare, but intermediate susceptibility significantly increased, especially after 2021 (OR per year, 1.42 [95% CI, 1.25\u20131.63]; P &amp;lt; .001). These findings highlight important recent shifts in antifungal susceptibility among C parapsilosis isolates, emphasizing the need for ongoing surveillance and stewardship.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf249","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:46:26Z","timestamp":1747035986000},"page":"1198-1202","source":"Crossref","is-referenced-by-count":11,"title":["Increasing Fluconazole Resistance in\n                    <i>Candida parapsilosis<\/i>\n                    : A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015\u20132024)"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-232X","authenticated-orcid":false,"given":"Jack","family":"McHugh","sequence":"first","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-6411","authenticated-orcid":false,"given":"Supavit","family":"Chesdachai","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Dunsirn","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Wengenack","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-3956","authenticated-orcid":false,"given":"Paschalis","family":"Vergidis","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"2025112208021560900_jiaf249-B1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(22)00872-6","article-title":"Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study","volume":"23","author":"Hoenigl","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"2025112208021560900_jiaf249-B2","doi-asserted-by":"crossref","DOI":"10.15620\/cdc:82532","volume-title":"Antibiotic resistance threats in the United States","author":"Centers for Disease Control and Prevention (CDC)","year":"2019"},{"key":"2025112208021560900_jiaf249-B3","doi-asserted-by":"crossref","first-page":"myad131","DOI":"10.1093\/mmy\/myad131","article-title":"Candida parapsilosis: a systematic review to inform the World Health Organization fungal priority pathogens list","volume":"62","author":"Asogan","year":"2024","journal-title":"Med Mycol"},{"key":"2025112208021560900_jiaf249-B4","doi-asserted-by":"crossref","first-page":"115957","DOI":"10.1016\/j.diagmicrobio.2023.115957","article-title":"Recent increase in fluconazole-nonsusceptible Candida parapsilosis in a global surveillance with the expansion of the Erg11 Y132F genotype and a rapid detection method for this alteration","volume":"106","author":"Hubler","year":"2023","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2025112208021560900_jiaf249-B5","volume-title":"WHO fungal priority pathogens list to guide research, development and public health action","author":"World Health Organization (WHO)","year":"2022"},{"key":"2025112208021560900_jiaf249-B6","doi-asserted-by":"crossref","first-page":"676177","DOI":"10.3389\/fcimb.2021.676177","article-title":"Clonal candidemia outbreak by Candida parapsilosis carrying Y132F in Turkey: evolution of a persisting challenge","volume":"11","author":"Arastehfar","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2025112208021560900_jiaf249-B7","doi-asserted-by":"crossref","first-page":"ofac605","DOI":"10.1093\/ofid\/ofac605","article-title":"Global emergence of resistance to fluconazole and voriconazole in Candida parapsilosis in tertiary hospitals in Spain during the COVID-19 pandemic","volume":"9","author":"Trevijano-Contador","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2025112208021560900_jiaf249-B8","doi-asserted-by":"crossref","first-page":"e01651-18","DOI":"10.1128\/AAC.01651-18","article-title":"Method-dependent epidemiological cutoff values for detection of triazole resistance in Candida and Aspergillus species for the Sensititre YeastOne colorimetric broth and Etest Agar diffusion methods","volume":"63","author":"Espinel-Ingroff","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2025112208021560900_jiaf249-B9","author":"Clinical and Laboratory Standards Institute"},{"key":"2025112208021560900_jiaf249-B10","doi-asserted-by":"crossref","first-page":"105799","DOI":"10.1016\/j.ijantimicag.2019.09.003","article-title":"Analysis of global antifungal surveillance results reveals predominance of Erg11 Y132F alteration among azole-resistant Candida parapsilosis and Candida tropicalis and country-specific isolate dissemination","volume":"55","author":"Castanheira","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"2025112208021560900_jiaf249-B11","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.scitotenv.2018.09.096","article-title":"Exposure of Candida parapsilosis complex to agricultural azoles: an overview of the role of environmental determinants for the development of resistance","volume":"650","author":"Brilhante","year":"2019","journal-title":"Sci Total Environ"},{"key":"2025112208021560900_jiaf249-B12","doi-asserted-by":"crossref","first-page":"dlaf040","DOI":"10.1093\/jacamr\/dlaf040","article-title":"Identification and antifungal susceptibility patterns of reference yeast strains to novel and conventional agents: a comparative study using CLSI, EUCAST and Sensititre YeastOne methods","volume":"7","author":"Ceballos-Garzon","year":"2025","journal-title":"JAC Antimicrob Resist"},{"key":"2025112208021560900_jiaf249-B13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.diagmicrobio.2012.05.008","article-title":"Comparison of the Sensititre YeastOne colorimetric antifungal panel with CLSI microdilution for antifungal susceptibility testing of the echinocandins against Candida spp., using new clinical breakpoints and epidemiological cutoff values","volume":"73","author":"Pfaller","year":"2012","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2025112208021560900_jiaf249-B14","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3906\/sag-1909-97","article-title":"Comparison of the Sensititre YeastOne antifungal method with the CLSI M27-A3 reference method to determine the activity of antifungal agents against clinical isolates of Candida spp","volume":"50","author":"Altinba\u015f","year":"2020","journal-title":"Turk J Med Sci"},{"key":"2025112208021560900_jiaf249-B15","doi-asserted-by":"crossref","first-page":"e0443122","DOI":"10.1128\/spectrum.04431-22","article-title":"Overestimation of amphotericin B resistance in Candida auris with Sensititre YeastOne antifungal susceptibility testing: a need for adjustment for correct interpretation","volume":"11","author":"Siopi","year":"2023","journal-title":"Microbiol Spectr"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiaf249\/63169418\/jiaf249.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/232\/5\/1198\/63169418\/jiaf249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/232\/5\/1198\/63169418\/jiaf249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T13:02:25Z","timestamp":1763816545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/232\/5\/1198\/8129863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,13]]},"published-print":{"date-parts":[[2025,11,14]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiaf249","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11,15]]},"published":{"date-parts":[[2025,5,13]]}}}