{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:06:16Z","timestamp":1793289976115,"version":"4.5.0"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K08 NS109332"],"award-info":[{"award-number":["K08 NS109332"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI163217"],"award-info":[{"award-number":["R01 AI163217"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI176646"],"award-info":[{"award-number":["R01 AI176646"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI007519"],"award-info":[{"award-number":["T32 AI007519"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01 EY09083"],"award-info":[{"award-number":["R01 EY09083"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rosaline Borison Memorial Fund Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The ability of herpes simplex virus (HSV) to establish lifelong latency in sensory neurons makes it one of the most pervasive viruses worldwide. Although most HSV infections are asymptomatic or cause limited cutaneous symptoms, some give rise to serious central nervous system (CNS) manifestations. Both primary HSV infection and subsequent reactivation events can cause viral replication and spread within the brain, ultimately leading to pathologic inflammation and direct CNS damage. In addition to fulminant presentations of HSV encephalitis, subclinical HSV CNS infections have been implicated in neurodevelopmental, cognitive, and neurodegenerative impairment. Here, we review the pathogenesis of HSV infection and resulting CNS manifestations across the human lifespan. Identifying the mechanisms of HSV-induced CNS damage, and therefore the populations at highest risk for neurological morbidity, may provide a better understanding of the role viruses play in neurological diseases and inform novel approaches to treatment.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf275","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:40:15Z","timestamp":1747993215000},"page":"14-24","source":"Crossref","is-referenced-by-count":11,"title":["Herpes Simplex Virus Neurovirulence Across the Human Lifespan"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-1653","authenticated-orcid":false,"given":"Abigail J","family":"Dutton","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon, New Hampshire ,","place":["USA"]},{"name":"Guarini School of Graduate and Advanced Studies, Dartmouth College , Hanover, New Hampshire ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cooper K","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Leib","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Lebanon, New Hampshire ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-4185","authenticated-orcid":false,"given":"Lisa N","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois ,","place":["USA"]},{"name":"Department of Pediatrics, Northwestern University Feinberg School of Medicine , Chicago, Illinois ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"Suppl 1","key":"2025073007425001100_jiaf275-B1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1086\/343739","article-title":"Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review","volume":"186","author":"Smith","year":"2002","journal-title":"J Infect Dis"},{"key":"2025073007425001100_jiaf275-B2","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/jama.296.8.964","article-title":"Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States","volume":"296","author":"Xu","year":"2006","journal-title":"JAMA"},{"key":"2025073007425001100_jiaf275-B3","author":"World 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