{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:03:19Z","timestamp":1785578599578,"version":"3.56.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI177604"],"award-info":[{"award-number":["1R01AI177604"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIA AI001175"],"award-info":[{"award-number":["ZIA AI001175"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida auris is an emerging multidrug-resistant fungal pathogen that uniquely colonizes the skin. The factors regulating C auris colonization are poorly understood. In this study, we examined the role of galectin-3 during C auris skin infection. We found that deletion of galectin-3 enhances the antifungal activity of neutrophils and increases resistance to C auris skin infection. Mechanistically, galectin-3 negatively regulates GLUT4 expression, glucose uptake, reactive oxygen species production, and fungal killing by neutrophils. Collectively, our findings uncover a detrimental role for galectin-3 in neutrophil-mediated defense against C auris.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf300","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T07:52:51Z","timestamp":1749023571000},"page":"e1043-e1047","source":"Crossref","is-referenced-by-count":2,"title":["Deletion of Galectin-3 Renders Mice Less Susceptible to\n                    <i>Candida auris<\/i>\n                    Skin Infection by Enhancing Antifungal Activity of Neutrophils"],"prefix":"10.1093","volume":"232","author":[{"given":"Shrihari M","family":"Ganesh","sequence":"first","affiliation":[{"name":"Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University , West Lafayette, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail S","family":"Lionakis","sequence":"additional","affiliation":[{"name":"Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-2392","authenticated-orcid":false,"given":"Shankar","family":"Thangamani","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University , West Lafayette, Indiana"},{"name":"Purdue Institute for Immunology, Inflammation and Infectious Diseases (PI4D) , West Lafayette, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"2026031304471595300_jiaf300-B1","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1056\/NEJMra2402635","article-title":"Candida auris infections","volume":"391","author":"Lionakis","year":"2024","journal-title":"N Engl J 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