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Here, we investigated if intranasal administration of the PRS regimen V antibiotics bedaquiline and delamanid on top of the oral regimen would further accelerate tuberculosis cure in mice. We show that adding the intranasal to oral regimen further lowers lung burden of tubercle bacilli and significantly more rapidly achieves relapse-free cure. Hence, adding inhalational to oral therapy can potentially accelerate cure of tuberculosis.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf315","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:21:15Z","timestamp":1749644475000},"page":"e442-e447","source":"Crossref","is-referenced-by-count":0,"title":["Adding Intranasal to Oral Administration of an Ultra-Rapid Near-Universal Drug Regimen Accelerates Relapse-Free Cure of Tuberculosis in Mice"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-1486","authenticated-orcid":false,"given":"Bai-Yu","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles , Los Angeles, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-7306","authenticated-orcid":false,"given":"Daniel 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