{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:03:22Z","timestamp":1773396202134,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Leishmaniasis is a vector-borne disease transmitted by female sand flies infected with Leishmania parasites. Cutaneous leishmaniasis is primarily caused by Leishmania major in the Old World and typically manifests as skin ulcers. The carbohydrate-rich molecules on the surface of Leishmania are crucial for the parasite's infectivity in the vertebrate host and vector. Among these, galactose moieties have been identified as promising targets for vaccines against leishmaniasis. This study investigates the potential of human monoclonal antibodies (mAbs) targeting \u03b1-Gal to prevent L major infection. Our results demonstrate that \u03b1-Gal\u2013specific mAbs effectively bind to and agglutinate metacyclic and procyclic L major promastigotes. To assess the protective efficacy of these mAbs, we challenged \u03b11,3-galactosyltransferase\u2013deficient mice with L major. The mAb AG030 significantly delayed the onset of skin lesions and reduced the parasite burden. These findings provide proof of principle that \u03b1-Gal\u2013targeting mAbs could serve as an intervention to prevent cutaneous leishmaniasis.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf350","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T08:00:35Z","timestamp":1751011235000},"page":"e481-e490","source":"Crossref","is-referenced-by-count":0,"title":["A Human Monoclonal Antibody Targeting \u03b1-Gal Ameliorates Experimental Cutaneous Leishmaniasis"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-1980","authenticated-orcid":false,"given":"Hyeseon","family":"Cho","sequence":"first","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Paun","sequence":"additional","affiliation":[{"name":"Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-4858","authenticated-orcid":false,"given":"Youngsil","family":"Seo","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-4161","authenticated-orcid":false,"given":"Maria","family":"Traver","sequence":"additional","affiliation":[{"name":"Imaging Facility, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-2950","authenticated-orcid":false,"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Protein Chemistry Section, Research Technologies Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-0442","authenticated-orcid":false,"given":"Jeff","family":"Skinner","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Tan","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-3124","authenticated-orcid":false,"given":"David L","family":"Sacks","sequence":"additional","affiliation":[{"name":"Intracellular Parasite Biology Section, Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-0412","authenticated-orcid":false,"given":"Peter D","family":"Crompton","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, 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