{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:41:54Z","timestamp":1785894114170,"version":"3.56.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32AI179104"],"award-info":[{"award-number":["F32AI179104"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI152210"],"award-info":[{"award-number":["R01AI152210"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI152209"],"award-info":[{"award-number":["R01AI152209"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lyme disease spirochetes are maintained in natural reservoirs before spilling over into human populations. Targeting these reservoirs with vaccinations or antibiotics could impact the Borrelia burgdorferi enzootic cycle and reduce the risk of human Lyme disease. In this work we report that the narrow-spectrum antibiotic hygromycin A is sufficient to disrupt B burgdorferi transmission from the main eastern US reservoir, Peromyscus leucopus, to ticks. Additionally, hygromycin A\u2013containing baits can clear B burgdorferi from P leucopus. These studies lay the foundation for the use of hygromycin A as a reservoir-targeted antibiotic to eradicate B burgdorferi in the wild.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf363","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T07:55:05Z","timestamp":1751615705000},"page":"96-100","source":"Crossref","is-referenced-by-count":3,"title":["Hygromycin A Treatment of\n                    <i>Borrelia burgdorferi<\/i>\n                    \u2013Infected\n                    <i>Peromyscus leucopus<\/i>\n                    Suggests Potential as a Reservoir-Targeted Antibiotic"],"prefix":"10.1093","volume":"233","author":[{"given":"Stephanie S","family":"You","sequence":"first","affiliation":[{"name":"Tufts Lyme Disease Initiative, Tufts University School of Medicine , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Molecular Biology and Microbiology, Tufts University School of Medicine , Boston, Massachusetts 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