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We performed vibriocidal antibody assays on 212 serum samples from 115 patients with culture-positive cholera (median age, 8 years) in Goma, Democratic Republic of Congo, which were collected at enrollment and 3 to 449 days after. Vibriocidal responses peaked at 7 to 40 days after symptom onset, with 89.5% waning to a titer \u2264160 by 180 days. 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