{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:37:46Z","timestamp":1792132666531,"version":"4.4.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI130170"],"award-info":[{"award-number":["R01AI130170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Maryland Baltimore"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida auris is associated with life-threatening invasive disease due to a high level of drug resistance. We present a clinical case of C. auris multidrug resistance development in a patient acquired during antifungal treatment. Five isolates were prospectively recovered from a lung transplant patient receiving antifungal therapy over a 1-year period. While isolates were initially only resistant to fluconazole, the terminal isolate became resistant to caspofungin and amphotericin B with significant increase in micafungin minimum inhibitory concentration. Sequencing of ERG11 and FKS1 genes identified mutations associated with fluconazole and echinocandin resistance in the multidrug-resistant isolate, underscoring the threat of therapy-induced development of resistance.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf394","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:33:18Z","timestamp":1753788798000},"page":"1203-1207","source":"Crossref","is-referenced-by-count":5,"title":["In Vivo Evolution of\n                    <i>Candida auris<\/i>\n                    Multidrug Resistance in a Patient Receiving Antifungal Treatment"],"prefix":"10.1093","volume":"232","author":[{"given":"Tristan W","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Putnam","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Clinical Microbiology Laboratory, Laboratories of Pathology, University of Maryland Medical Center , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Kristie","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Clinical Microbiology Laboratory, Laboratories of Pathology, University of Maryland Medical Center , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-3873","authenticated-orcid":false,"given":"Mary Ann","family":"Jabra-Rizk","sequence":"additional","affiliation":[{"name":"Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"2025112208030683000_jiaf394-B1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev-micro-032521-015858","article-title":"Candida auris genetics and emergence","volume":"77","author":"Chowdhary","year":"2023","journal-title":"Annu Rev Microbiol"},{"key":"2025112208030683000_jiaf394-B2","doi-asserted-by":"crossref","first-page":"e0091124","DOI":"10.1128\/aac.00911-24","article-title":"What makes Candida auris pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugs","volume":"68","author":"Rhodes","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"key":"2025112208030683000_jiaf394-B3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41579-023-00861-x","article-title":"The WHO fungal priority pathogens list as a game-changer","volume":"21","author":"Fisher","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"2025112208030683000_jiaf394-B4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/myc.13655","article-title":"Whole genome sequencing analysis demonstrates therapy-induced echinocandin resistance in Candida auris 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