{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:54:26Z","timestamp":1773395666031,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI142708"],"award-info":[{"award-number":["AI142708"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI58615"],"award-info":[{"award-number":["AI58615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malaria begins when an infected mosquito injects saliva containing Plasmodium sporozoites into the host skin. The immune response against a mosquito saliva protein, AgTRIO, reduces Plasmodium infection and can work in combination with antibody against the Plasmodium circumsporozoite protein (CSP). We have now developed a chimeric peptide, PfAg, containing regions from Plasmodium falciparum CSP (PfCSP) and AgTRIO. Mice administered PfAg generated robust humoral responses against both PfCSP and AgTRIO. After exposure to PfCSP-expressing Plasmodium berghei\u2013infected mosquitoes, PfAg-immunized inbred C57BL\/6 and outbred CD-1 mice had significantly improved survival compared with control animals. These data will aid in the development of a new malaria vaccine.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf432","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:33:10Z","timestamp":1754998390000},"page":"e496-e500","source":"Crossref","is-referenced-by-count":0,"title":["A Multivalent Peptide Vaccine Against Malaria, Targeting\n                    <i>Plasmodium<\/i>\n                    Circumsporozoite Protein and Mosquito AgTRIO"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2241-5541","authenticated-orcid":false,"given":"Yu-Min","family":"Chuang","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Ledizet","sequence":"additional","affiliation":[{"name":"L2 Diagnostics , New Haven, Connecticut 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