{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T04:03:24Z","timestamp":1784520204299,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5T32AI007044"],"award-info":[{"award-number":["5T32AI007044"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DMID 11-0042"],"award-info":[{"award-number":["DMID 11-0042"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201300019I"],"award-info":[{"award-number":["HHSN272201300019I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ensuring the safety and efficacy of candidate vaccines is critical. Although mechanisms underpinning protective immune responses to malaria vaccines are frequently investigated, immune responses correlating with moderate and severe adverse events (AEs) are rarely examined. Here, we leverage a malaria vaccine trial with a higher-than-expected AE rate and frequent sampling to investigate cytokine profiles associated with AEs. We found that Interleukin-6 was elevated on days in which individuals experienced moderate and severe AEs. More research on immune responses associated with AEs is warranted in order to identify biomarkers associated with systemic reactogenicity and accelerate vaccine development.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf435","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:46:52Z","timestamp":1755085612000},"page":"191-196","source":"Crossref","is-referenced-by-count":0,"title":["Cytokines Associated With Moderate and Severe Adverse Events During a Sporozoite Malaria Vaccine Trial With Controlled Human Malaria Infection"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-9046","authenticated-orcid":false,"given":"Lauren P","family":"Jatt","sequence":"first","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center , Seattle, Washington"},{"name":"Division of Allergy and Infectious Disease, University of Washington , Seattle, 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