{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:15:01Z","timestamp":1777774501265,"version":"3.51.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Doxycycline post-exposure prophylaxis is now included in many clinical guidelines, yet concerns remain regarding antimicrobial resistance, particularly off-target effects on commensal bacteria in the oropharynx, with intimate behaviours potentially facilitating resistance transmission within sexual networks.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf439","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:20:35Z","timestamp":1755516035000},"page":"625-627","source":"Crossref","is-referenced-by-count":1,"title":["Doxycycline Post-exposure Prophylaxis and Off-target Antimicrobial Resistance: Potential Amplification Within Sexual Networks"],"prefix":"10.1093","volume":"233","author":[{"given":"Manon","family":"Roberts","sequence":"first","affiliation":[{"name":"Medical Sciences Division, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-2566","authenticated-orcid":false,"given":"Peter","family":"Davis","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, University of Oxford , Oxford ,","place":["United Kingdom"]},{"name":"Department of Microbiology, Oxford University Hospitals NHS Foundation Trust , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"2026042913464584700_jiaf439-B1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1136\/sextrans-2024-056208","article-title":"Efficacy of postexposure prophylaxis with doxycycline (Doxy-PEP) in reducing sexually transmitted infections: a systematic review and meta-analysis","volume":"101","author":"Sokoll","year":"2025","journal-title":"Sex Transm Infect"},{"key":"2026042913464584700_jiaf439-B2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae062","article-title":"Filling in the gaps: updates on doxycycline prophylaxis for bacterial sexually transmitted infections [published online ahead of print Feb 9, 2024]","author":"Hazra","journal-title":"Clin Infect Dis"},{"key":"2026042913464584700_jiaf439-B3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41591-024-03274-2","article-title":"Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome","volume":"31","author":"Chu","year":"2025","journal-title":"Nat Med"},{"key":"2026042913464584700_jiaf439-B4","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/cid\/ciaf089","article-title":"Potential impact of doxycycline post-exposure prophylaxis on tetracycline resistance in Neisseria gonorrhoeae and colonization with tetracycline-resistant Staphylococcus aureus and group A Streptococcus","volume":"80","author":"Soge","year":"2025","journal-title":"Clin Infect Dis"},{"key":"2026042913464584700_jiaf439-B5","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.1016\/S1473-3099(23)00359-6","article-title":"Selection of Neisseria gonorrhoeae ceftriaxone resistance using doxycycline post-exposure prophylaxis","volume":"23","author":"Whiley","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"2026042913464584700_jiaf439-B6","doi-asserted-by":"crossref","first-page":"25017","DOI":"10.1038\/s41598-024-75130-9","article-title":"Carriage and antimicrobial susceptibility of commensal Neisseria species from the human oropharynx","volume":"14","author":"Miari","year":"2024","journal-title":"Sci Rep"},{"key":"2026042913464584700_jiaf439-B7","doi-asserted-by":"crossref","first-page":"e0044123","DOI":"10.1128\/msphere.00441-23","article-title":"Evolution and exchange of plasmids in pathogenic Neisseria","volume":"8","author":"Yee","year":"2023","journal-title":"mSphere"},{"key":"2026042913464584700_jiaf439-B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-96244-8","article-title":"Revisiting the potential impact of doxycycline post-exposure prophylaxis on the selection of doxycycline resistance in Neisseria commensals","volume":"15","author":"Robinson","year":"2025","journal-title":"Sci Rep"},{"key":"2026042913464584700_jiaf439-B9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/OLQ.0000000000001777","article-title":"A systematic review of kissing as a risk factor for oropharyngeal gonorrhea or Chlamydia","volume":"50","author":"Charleson","year":"2023","journal-title":"Sex Transm Dis"},{"key":"2026042913464584700_jiaf439-B10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/pathogens9030228","article-title":"Commensal Neisseria are shared between sexual partners: implications for gonococcal and meningococcal antimicrobial resistance","volume":"9","author":"Van Dijck","year":"2020","journal-title":"Pathogens"},{"key":"2026042913464584700_jiaf439-B11","doi-asserted-by":"crossref","first-page":"1308550","DOI":"10.3389\/fcimb.2023.1308550","article-title":"Non-pathogenic Neisseria species of the oropharynx as a reservoir of antimicrobial resistance: a cross-sectional study","volume":"13","author":"Gaspari","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"2026042913464584700_jiaf439-B12","doi-asserted-by":"crossref","first-page":"12381","DOI":"10.1073\/pnas.95.21.12381","article-title":"Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens","volume":"95","author":"Kroll","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026042913464584700_jiaf439-B13","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1177\/09564624231190108","article-title":"Doxycycline post exposure prophylaxis could select for cross-resistance to other antimicrobials in various pathogens: an in silico analysis","volume":"34","author":"Gestels","year":"2023","journal-title":"Int J STD AIDS"},{"key":"2026042913464584700_jiaf439-B14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1056\/NEJMc2504010","article-title":"Expansion of tetM-carrying Neisseria gonorrhoeae in the United States, 2018\u20132024","volume":"393","author":"Helekal","year":"2025","journal-title":"N Engl J Med"},{"key":"2026042913464584700_jiaf439-B15","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1016\/S2666-5247(23)00314-2","article-title":"Estimating changes in antibiotic consumption with the introduction of doxycycline post-exposure prophylaxis in the United States","volume":"5","author":"Roster","year":"2023","journal-title":"The Lancet Microbe"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiaf439\/64085535\/jiaf439.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/233\/4\/625\/64085535\/jiaf439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/233\/4\/625\/64085535\/jiaf439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:46:55Z","timestamp":1777484815000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/233\/4\/625\/8238236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,20]]},"published-print":{"date-parts":[[2026,4,29]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiaf439","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4,15]]},"published":{"date-parts":[[2025,8,20]]}}}