{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:53:05Z","timestamp":1787997185986,"version":"build-2784847793"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mycobacterium tuberculosis (MTB) remains a major cause of global mortality, yet natural immunity prevents disease in more than 90% of exposed individuals. Interferon gamma (IFN-\u03b3) is a critical regulator of innate immunity and enhances macrophage antimicrobial responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using in vitro systems approaches, we compared the effects of IFN-\u03b3 exposure before versus after infection. We manipulated c-Myc in primary macrophages with a tetracycline-inducible lentiviral system. c-Myc expression was also analyzed in tissues from murine tuberculosis models and human granulomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preinfection IFN-\u03b3 exposure primed macrophages for enhanced bacterial control, whereas postinfection exposure did not. We identified c-Myc signaling as a central determinant of macrophage antimycobacterial function. Inhibition of c-Myc via Omomyc enhanced bacterial control partly through mTORC1-dependent metabolic reprogramming and nitric oxide production. In vivo analyses, including murine models and human clinical histopathology, revealed strong associations between c-Myc expression, MTB persistence, and active tuberculosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>c-Myc mediates immune privilege in MTB infection and represents a promising target for host-directed therapies to enhance macrophage function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf456","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:31:20Z","timestamp":1756207880000},"page":"e691-e703","source":"Crossref","is-referenced-by-count":3,"title":["c-Myc Inhibits Macrophage Antimycobacterial Response in\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Infection"],"prefix":"10.1093","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5623-7783","authenticated-orcid":false,"given":"Edoardo","family":"Sarti","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8297-0632","authenticated-orcid":false,"given":"C\u00e9dric","family":"Doll\u00e9","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3782-9691","authenticated-orcid":false,"given":"Rebekka","family":"Wolfensberger","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-1940","authenticated-orcid":false,"given":"Katharina","family":"Kusejko","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich , Zurich ,","place":["Switzerland"]},{"name":"Institute of Medical Virology, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Russenberger","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich , Zurich 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