{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:36:06Z","timestamp":1789029366215,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI141602"],"award-info":[{"award-number":["AI141602"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI1089683"],"award-info":[{"award-number":["U19AI1089683"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sequestration of Plasmodium falciparum\u2013infected erythrocytes (IE) in the microvasculature is a major virulence determinant. While the sequestration of mature stage parasites (trophozoite and schizonts) to vascular endothelium is well established, the conditions that promote ring-stage IE sequestration are less understood. Here, we observed in ring-stage parasites that febrile exposure increased transcript levels of several exported parasite genes involved in the trafficking of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) ligand responsible for adherence to the endothelium of blood vessels. Furthermore, it accelerated PfEMP1 surface display in ring-stage IEs, leading to a 2-fold increase in their binding in a perfusable 3D human brain microvessel model. Additionally, we observed that parasite exposure enhances the binding of uninfected erythrocytes in 3D brain microvessels. These findings suggest a complex interplay between fever and parasite biomass in the pathogenesis of cerebral malaria.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf474","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:39:00Z","timestamp":1757417940000},"page":"e1215-e1225","source":"Crossref","is-referenced-by-count":2,"title":["Febrile Temperature Augments Ring-stage\n                    <i>Plasmodium falciparum<\/i>\n                    Adhesion to Brain Endothelial Cells"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9731-9239","authenticated-orcid":false,"given":"Fatou","family":"Joof","sequence":"first","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children's Research Institute , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6103-4063","authenticated-orcid":false,"given":"Ruoqian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-9549","authenticated-orcid":false,"given":"Karl B","family":"Seydel","sequence":"additional","affiliation":[{"name":"Blantyre Malaria Project, Kamuzu University of Health Sciences , Blantyre ,","place":["Malawi"]},{"name":"Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University , East Lansing, Michigan ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7575-630X","authenticated-orcid":false,"given":"Lauren M","family":"Cohee","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine , Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2723-9022","authenticated-orcid":false,"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7915-6360","authenticated-orcid":false,"given":"Joseph D","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research, Seattle Children's Research Institute , Seattle, Washington ,","place":["USA"]},{"name":"Department of Pediatrics, School of Medicine, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"2026051419581303700_jiaf474-B1","first-page":"385","article-title":"Human cerebral malaria. 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