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We used a global panel of lineage-specific natural infection sera to assess antibody-binding specificity for lineage-specific L1L2 antigens, and we used these data to create relational antigenic maps. Merging these data with neutralizing antibody data demonstrated similar spatial geometry and revealed dependency on a limited number of amino residues on the capsid surface. These data inform the degree of lineage specificity within the natural infection humoral immune response to oncogenic human papillomaviruses.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf502","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:11:19Z","timestamp":1758888679000},"page":"e145-e150","source":"Crossref","is-referenced-by-count":1,"title":["Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies"],"prefix":"10.1093","volume":"233","author":[{"given":"Kavita","family":"Panwar","sequence":"first","affiliation":[{"name":"Virus Reference Department, Public Health Microbiology Division, UK Health Security Agency , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-185X","authenticated-orcid":false,"given":"Kazutomo","family":"Yokoya","sequence":"additional","affiliation":[{"name":"Virus 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