{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:34:53Z","timestamp":1778250893783,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2014-57941"],"award-info":[{"award-number":["200-2014-57941"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["75D30118P01518"],"award-info":[{"award-number":["75D30118P01518"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["75D30119C05084"],"award-info":[{"award-number":["75D30119C05084"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marshfield Clinic Health System Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A third dose of measles, mumps, and rubella vaccine (MMR3) may be administered in outbreak and nonoutbreak settings. However, data on long-term immunogenicity to the mumps component of MMR are limited. We examined durability of mumps antibody response among adults up to 11 years after receipt of MMR3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Persons who received MMR3 at ages 18\u201328 years had sera collected before (baseline), 1 month, 1, 5, and 9\u201311 years after vaccination. Mumps antibodies were assessed by plaque reduction neutralization, immunoassay (EIA), and immunoglobulin G (IgG) avidity. Neutralizing antibodies were assessed against the vaccine strain (Genotype A) and a wild-type virus from Genotype G. Participants with neutralizing antibody titers &amp;lt;31 for Genotype A and &amp;lt;8 for Genotype G, and with EIA index values &amp;lt;1.10 were considered potentially susceptible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among participants with data for all visits after MMR3 (40%, n = 262\/655), susceptibility based on Genotype A titers increased from 15.7% (41\/262) at baseline to 30.5% (80\/262) 9\u201311 years after vaccination while susceptibility based on Genotype G titers remained relatively stable (30.2%\u201324.2%). The proportion of participants seronegative for mumps IgG by EIA increased from 0% (0\/255) at baseline to 7.5% (19\/255) 9\u201311 years after vaccination. The avidity index increased from 52% to 67% through Year 5 (P &amp;lt; .0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By 9\u201311 years after receipt of MMR3, many participants had mumps antibody levels that predicted susceptibility to infection, comparable to those observed before receipt of MMR3. The antibody titers to Genotype G remained consistently lower than the titers to the vaccine strain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf520","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T13:08:56Z","timestamp":1763125736000},"page":"e383-e391","source":"Crossref","is-referenced-by-count":2,"title":["Durability of the Mumps Antibody Response After the Third Dose of MMR Vaccine"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-5252","authenticated-orcid":false,"given":"Sun B","family":"Sowers","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2725-6439","authenticated-orcid":false,"given":"Huong Q","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute , Marshfield, Wisconsin ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-6058","authenticated-orcid":false,"given":"Nina B","family":"Masters","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3567-0381","authenticated-orcid":false,"given":"Sara","family":"Mercader","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-4075","authenticated-orcid":false,"given":"Heather","family":"Colley","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-7190","authenticated-orcid":false,"given":"David L","family":"McClure","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute , Marshfield, Wisconsin ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-8151","authenticated-orcid":false,"given":"Carole J","family":"Hickman","sequence":"additional","affiliation":[{"name":"Division of Viral 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