{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:15:51Z","timestamp":1785176151107,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Insititutes of Health and Care Research","award":["RP-PG-0707-10034"],"award-info":[{"award-number":["RP-PG-0707-10034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epstein-Barr virus (EBV) causes most nasopharyngeal carcinoma (NPC), a malignancy endemic in certain regions, presenting with nonspecific symptoms and lacking a robust minimally invasive biomarker. To assess previously developed multiplex Luminex assay EBV antibody signatures in a nonendemic population, we analyzed and compared 98 NPC sera and 142 matched controls from the nonendemic Head and Neck 5000 clinical cohort against an endemic Taiwan case-control cohort. All models, except the 2-antibody IgA panel, performed similarly, achieving 90%\u201399% accuracy in identifying EBV-positive NPC. Our results showed that EBV antibody panels can accurately define EBV-positive NPC regardless of endemicity.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf526","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:00:51Z","timestamp":1760097651000},"page":"e404-e408","source":"Crossref","is-referenced-by-count":2,"title":["Epstein-Barr Virus Antibody Response Patterns in Endemic and Nonendemic Cases of Nasopharyngeal Carcinoma"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4925-5296","authenticated-orcid":false,"given":"Ilona","family":"Argirion","sequence":"first","affiliation":[{"name":"Department of Human Science, School of Health, Georgetown University Medical Center , Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-6955","authenticated-orcid":false,"given":"Aisha","family":"Babi","sequence":"additional","affiliation":[{"name":"Division of Infections and Cancer Epidemiology, German Cancer Research Center , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Simon","sequence":"additional","affiliation":[{"name":"Division of Infections and Cancer Epidemiology, German Cancer Research Center , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-6963","authenticated-orcid":false,"given":"Tim","family":"Waterboer","sequence":"additional","affiliation":[{"name":"Division of Infections and Cancer Epidemiology, German Cancer Research Center , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Lun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Data Science Center"},{"name":"Master Program of Big Data in Medical Healthcare Industry, College of Medicine, Fu-Jen Catholic University , New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-9069","authenticated-orcid":false,"given":"Chien-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Genomics Research Center, Academica Sinica , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-6586","authenticated-orcid":false,"given":"Kelly J","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4658-5772","authenticated-orcid":false,"given":"Miranda","family":"Pring","sequence":"additional","affiliation":[{"name":"Bristol Dental School, University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Hurley","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol , Bristol ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-2363","authenticated-orcid":false,"given":"Allan","family":"Hildesheim","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-651X","authenticated-orcid":false,"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Science, School of Health, Georgetown University Medical Center , Washington, DC"},{"name":"Division of 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