{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:57:50Z","timestamp":1781567870970,"version":"3.54.5"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/01760"],"award-info":[{"award-number":["PI23\/01760"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Subprograme Miguel Servet"},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa"},{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Spain","award":["CP24\/00137"],"award-info":[{"award-number":["CP24\/00137"]}]},{"name":"Subprograme Juan Rod\u00e9s"},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa"},{"name":"Ministerio de Ciencia"},{"name":"Innovaci\u00f3n y Universidades, Spain","award":["JR20\/00023"],"award-info":[{"award-number":["JR20\/00023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this work, we present the genomic characterization of a clinical Salmonella enterica serovar Rissen isolate harboring a novel IncN2 plasmid carrying the blaKPC-2 gene. The identified plasmid (pSEay-KPC) also encoded additional resistance genes, including blaACC-1, blaTEM-1, and qnrB. The pSEay-KPC conferred broad-spectrum antimicrobial resistance, allowing the pathogen to survive two consecutive antibiotic therapies with ceftriaxone and ciprofloxacin. Effective treatment was ultimately achieved with meropenem\u2013vaborbactam, a last-resort agent. These findings highlight IncN2 plasmids as potent vectors for the spread of clinically significant resistance genes, enabling bacteria to evade frontline antimicrobials and complicating infection management.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf536","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:23:34Z","timestamp":1760531014000},"page":"328-333","source":"Crossref","is-referenced-by-count":1,"title":["Novel KPC-2 Plasmid in a Clinical\n                    <i>Salmonella<\/i>\n                    Rissen Selected by Antibiotic Pressure"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-8414","authenticated-orcid":false,"given":"Mar\u00eda","family":"Aznar Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University Hospital Virgen del Roc\u00edo , Seville ,","place":["Spain"]},{"name":"Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville , Seville ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-9724","authenticated-orcid":false,"given":"\u00c1ngel","family":"Rodr\u00edguez-Villodres","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University Hospital Virgen del Roc\u00edo , Seville ,","place":["Spain"]},{"name":"Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville , Seville ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University Hospital Virgen del Roc\u00edo , Seville ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-672X","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Cisneros","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University Hospital Virgen del Roc\u00edo , Seville ,","place":["Spain"]},{"name":"Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville , Seville ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC) , Madrid ,","place":["Spain"]},{"name":"Department of Medicine, Faculty of Medicine, University of Seville , Seville ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2899-7207","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Ortiz de la Rosa","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University Hospital Virgen del Roc\u00edo , Seville ,","place":["Spain"]},{"name":"Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Roc\u00edo\/CSIC\/University of Seville , Seville ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3635-4930","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Lepe","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, University 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