{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:56:32Z","timestamp":1773762992781,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"German Center for Infection Research","doi-asserted-by":"publisher","award":["8008803814"],"award-info":[{"award-number":["8008803814"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Schistosomiasis and malaria are major poverty-related parasitic infectious diseases. They are often coendemic and affect similar target populations. Mass drug administration and intermittent preventive treatment programs are commonly used for their control. From a programmatic perspective the establishment of preventive treatment programs targeting both diseases simultaneously would be a great advantage. While there is preliminary evidence that certain antimalarial drugs exert a clinically important effect on Schistosomes, little is known on whether praziquantel (PZQ), the only licensed drug to treat schistosomiasis, has activity against Plasmodium parasites. Therefore, the CORMA-MAL study was conducted to evaluate antimalarial activity of PZQ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This double-blinded, randomized, placebo-controlled phase 2b trial was conducted in Lambar\u00e9n\u00e9, Gabon and recruited semi-immune adults with an asymptomatic Plasmodium falciparum parasitemia. Participants were randomized (1:1) to receive placebo or 40\u2005mg\/kg PZQ once daily for 3 days and followed up for a total of 7 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-four participants were recruited. Analytical models indicated a highly significant hourly reduction of microscopically determined parasitemia in the PZQ arm and a nonsignificant decreasing trend in the placebo group (regression slopes of log10-transformed parasitemia: \u03b2=\u22120.006 [P &amp;lt; .001] and \u03b2=\u22120.0013 [P = .3], respectively). However, in total only 9 of 22 (41%) in the PZQ arm compared to 6 of 22 (27%) in the placebo arm reached parasite clearance by day 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings demonstrate a statistically significant antimalarial activity of PZQ; however, the observed effect is only moderate compared to current first-line antimalarial treatments. Future research should investigate the synergistic potential of combining PZQ and antimalarial drugs in malaria and schistosomiasis control.<\/jats:p>\n                    <jats:p>Clinical Trials Registration.Pan African Clinical Trials Registry, PACTR202206584817951, 10 June 2022 (https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=22586).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf544","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:45:16Z","timestamp":1761655516000},"page":"e731-e739","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Praziquantel for Treatment of\n                    <i>Plasmodium falciparum<\/i>\n                    Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-6327","authenticated-orcid":false,"given":"Johannes","family":"Mischlinger","sequence":"first","affiliation":[{"name":"Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I Dept. of Medicine University Medical Center Hamburg-Eppendorf, Hamburg ,","place":["Germany"]},{"name":"German Centre for Infection Research, Partner Site Hamburg-Luebeck-Borstel , Hamburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8423-7554","authenticated-orcid":false,"given":"Klara","family":"Pechmann","sequence":"additional","affiliation":[{"name":"Center for Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I Dept. of Medicine University Medical Center Hamburg-Eppendorf, Hamburg ,","place":["Germany"]},{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9 , Lambar\u00e9n\u00e9 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