{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T07:17:24Z","timestamp":1781421444234,"version":"3.54.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR003015"],"award-info":[{"award-number":["UL1TR003015"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR003016"],"award-info":[{"award-number":["KL2TR003016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI187708"],"award-info":[{"award-number":["K23AI187708"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adenovirus (AdV) 40\/41 is a major cause of pediatric acute gastroenteritis (AGE), leading to significant morbidity and mortality worldwide. As little is known about clinical correlates of protection, we analyzed AdV-specific antibody reactivities using a multi-AdV protein microarray and serum from a Bangladeshi birth cohort surveilled for diarrhea during the first 2 years of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Arrays contained a comprehensive set of proteins from AdV 40 and 41, in addition to respiratory AdVs 4, 5, and 26. Children were split into four groups according to AdV 40\/41 infection occurrence during year 1 (Y1) and year 2 (Y2) of life. One-year array antibody reactivity levels were analyzed from 119 children using principal component analysis (PCA). Top antibody reactivities were evaluated for associations with AdV 40\/41 disease severity and protection in Year 2 using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight principal components (PCs) were identified from PCA. Top targets contributing to the leading PCs included external AdV 40\/41 antigens that function in host cell entry, particularly penton base (PB) proteins. AdV 41 PB antibody reactivity at Year 1 is significantly associated with reduced risk of AdV 40\/41 infection in Year 2 (OR = 0.36, 95% CI: 0.16\u20130.80, P = .013, adjusted P = .003). Additionally, those with mild to moderate infections in Year 2 had higher reactivities to AdV 40 and 41 PB compared to severe infections (P = .008 and .032, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher antibody reactivity to AdV PB was associated with improved Year 2 AdV 40\/41 outcomes, elevating it as a promising vaccine or monoclonal antibody target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf558","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:21:31Z","timestamp":1762647691000},"page":"e430-e440","source":"Crossref","is-referenced-by-count":1,"title":["Adenovirus 40 and 41 Antibodies Associated With Protection From Infection in a Bangladeshi Birth Cohort"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-2596","authenticated-orcid":false,"given":"Jennifer","family":"Hendrick","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Virginia Health System , Charlottesville, Virginia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-2882","authenticated-orcid":false,"given":"Jennie Z","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Virginia School of Medicine , Charlottesville, Virginia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu","family":"Huynh","sequence":"additional","affiliation":[{"name":"Antigen Discovery Incorporated (ADI) , Irvine California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-7688","authenticated-orcid":false,"given":"Jozelyn V","family":"Pablo","sequence":"additional","affiliation":[{"name":"Antigen Discovery Incorporated (ADI) , Irvine California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy A","family":"Teng","sequence":"additional","affiliation":[{"name":"Antigen Discovery Incorporated (ADI) , Irvine California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2384-8890","authenticated-orcid":false,"given":"Amit","family":"Oberai","sequence":"additional","affiliation":[{"name":"Antigen Discovery Incorporated (ADI) , Irvine California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-0917","authenticated-orcid":false,"given":"Joseph J","family":"Campo","sequence":"additional","affiliation":[{"name":"Antigen Discovery Incorporated (ADI) , Irvine California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-5951","authenticated-orcid":false,"given":"David","family":"Camerini","sequence":"additional","affiliation":[{"name":"Antigen Discovery Incorporated (ADI) , Irvine California ,","place":["USA"]},{"name":"Center for Virus Research, University of California , Irvine, California ,","place":["USA"]},{"name":"Department of Developmental and Cell Biology, University of California , Irvine, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William A","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Virginia Health System , Charlottesville, Virginia ,","place":["USA"]},{"name":"Department of Microbiology, Immunology and Cancer Biology, 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