{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T10:05:12Z","timestamp":1773396312551,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI150797"],"award-info":[{"award-number":["R01AI150797"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI178158"],"award-info":[{"award-number":["R21AI178158"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32OD011126"],"award-info":[{"award-number":["T32OD011126"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Johnson Family Livestock Endowment for Veterinary Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brucellosis is a significant zoonotic disease throughout the world. Human brucellosis patients develop flu-like symptoms and focal complications including arthritis and neurobrucellosis, which is the most morbid complication of Brucella infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we employed murine models to uncover the role of T-cell\u2013mediated immunity, interferons, and signal transducers and activators of transcription (STAT) signaling in the development of neurobrucellosis caused by Brucella melitensis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Through adoptive transfer experiments, we discovered that T cells are recruited to the brains of Brucella-infected mice and are able to prevent central nervous system infection in an interferon-\u03b3 (IFN-\u03b3)\u2013dependent manner. Transferred T cells were also able to reduce established colonization of the brain by Brucella. In addition, we found that STAT1 plays a protective role against colonization of the brain by Brucella and the progression of neurobrucellosis, and that IFN-\u03b3 signaling is not entirely essential for these protective effects. While STAT2 deficiency alone did not affect Brucella burdens, a combined deficiency of STAT2 and the IFN-\u03b3 receptor led to elevated Brucella burdens in brains and blood, and a higher likelihood of developing neurologic symptoms relative to animals lacking the IFN-\u03b3 receptor alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that T cells and IFN signaling through both STAT1 and STAT2 play complex and important roles in protecting against bacterial colonization and development of neurologic symptoms following infection by Brucella.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf565","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:03:02Z","timestamp":1762606982000},"page":"e322-e331","source":"Crossref","is-referenced-by-count":0,"title":["Signal Transducers and Activators of Transcription 1 (STAT1), STAT2, and T Cells Mediate Interferon-Dependent Protection Against Neurobrucellosis"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-3450","authenticated-orcid":false,"given":"Charles R","family":"Moley","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri , Columbia, Missouri ,","place":["USA"]},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia, Missouri ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-3800","authenticated-orcid":false,"given":"Mostafa F N","family":"Abushahba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri , Columbia, Missouri ,","place":["USA"]},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia, Missouri ,","place":["USA"]},{"name":"Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University , Assiut ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5679-5242","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Ponzilacqua-Silva","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri , Columbia, Missouri ,","place":["USA"]},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia, Missouri ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Kochetkova","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, Montana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-2222","authenticated-orcid":false,"given":"Christa D","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, Montana ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-908X","authenticated-orcid":false,"given":"Jerod A","family":"Skyberg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri , Columbia, Missouri ,","place":["USA"]},{"name":"Laboratory for Infectious Disease Research, University of Missouri , Columbia, Missouri ,","place":["USA"]},{"name":"Department of Microbiology and Cell Biology, Montana State University , Bozeman, Montana 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