{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:32:03Z","timestamp":1793071923432,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programme of Enhancing Laboratory Surveillance"},{"name":"Investigation of Emerging Infectious Diseases and Antimicrobial Resistance"},{"DOI":"10.13039\/100004856","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Special Administrative Region government"},{"name":"InnoHK"},{"name":"Hong Kong Special Administrative Region government"},{"name":"Shaw Foundation Hong Kong"},{"name":"Michael Seak-Kan Tong"},{"name":"Lee Wan Keung Charity Foundation Limited"},{"name":"Providence Foundation Limited"},{"name":"Hong Kong Sanatorium & Hospital","id":[{"id":"https:\/\/ror.org\/010mjn423","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Respiratory Viral Research Foundation Limited"},{"name":"Chow Sin Lan Charity Fund Limited"},{"name":"Chan Yin Chuen Memorial Charitable Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Three critically ill or fatal avian influenza A(H5N1) human infections have been reported in North America since November 2024. Notably, all were infected with genotype D1.1 instead of B3.13, the dominant genotype before November 2024. Here, we demonstrated that D1.1 could replicate to higher titers in human nasal and airway organoid\u2013derived transwell monolayers from 6 donors. D1.1 exhibited a better binding to \u03b12,3- and \u03b12,6-linked sialic acid than B3.13. No significant differences in most inflammatory or antiviral cytokines\/chemokines were observed. These observations suggest that D1.1 is better adapted to both the upper and lower human respiratory tract epithelium than B3.13.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf598","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T12:58:37Z","timestamp":1763816317000},"page":"e662-e666","source":"Crossref","is-referenced-by-count":13,"title":["Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13"],"prefix":"10.1093","volume":"233","author":[{"given":"Xiaojuan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, University of Hong Kong , Pokfulam, Hong Kong Special Administrative Region ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Joy-Ann","family":"Lam","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, University of Hong Kong , Pokfulam, Hong Kong Special Administrative Region ,","place":["People's Republic of China"]},{"name":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park , Pak Shek Kok, Hong Kong Special Administrative Region ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, University of Hong Kong , Pokfulam, Hong Kong Special Administrative Region ,","place":["People's Republic of 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Special Administrative Region ,","place":["People's Republic of China"]},{"name":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park , Pak Shek Kok, Hong Kong Special Administrative Region ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Chun-Yee","family":"Tam","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, University of Hong Kong , Pokfulam, Hong Kong Special Administrative Region ,","place":["People's Republic of China"]},{"name":"Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park , Pak Shek Kok, Hong Kong Special Administrative Region ,","place":["People\u2019s Republic of 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,","place":["People's Republic of China"]},{"name":"Department of Infectious Disease and Microbiology, The University of Hong Kong\u2013Shenzhen Hospital , Shenzhen ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"2026031710044025100_jiaf598-B1"},{"key":"2026031710044025100_jiaf598-B2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1056\/NEJMc2415890","article-title":"Critical illness in an adolescent with influenza A(H5N1) virus infection","volume":"392","author":"Jassem","year":"2024","journal-title":"N Engl J Med"},{"key":"2026031710044025100_jiaf598-B3"},{"key":"2026031710044025100_jiaf598-B4"},{"key":"2026031710044025100_jiaf598-B5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1056\/NEJMoa2414610","article-title":"Highly pathogenic avian influenza A(H5N1) virus infections in 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