{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:04:16Z","timestamp":1778133856910,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100031003","name":"CDC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021930","name":"USAID","doi-asserted-by":"publisher","award":["AID-GH-T15-00002"],"award-info":[{"award-number":["AID-GH-T15-00002"]}],"id":[{"id":"10.13039\/100021930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009054","name":"US President's Emergency Plan for AIDS Relief","doi-asserted-by":"publisher","award":["AID-OAA-A-14-00010"],"award-info":[{"award-number":["AID-OAA-A-14-00010"]}],"id":[{"id":"10.13039\/100009054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CONRAD"},{"DOI":"10.13039\/100013965","name":"Eastern Virginia Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009980","name":"Old Dominion University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009980","id-type":"DOI","asserted-by":"publisher"}]},{"name":"USG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>On-demand topical inserts for HIV prevention may be a good option for people who have a low frequency of sexual activity. We recently demonstrated in a preclinical macaque model that rectal application of inserts containing tenofovir alafenamide fumarate (TAF) and elvitegravir (EVG) conferred protection against SHIV infection (93% efficacy) when applied as pre-exposure prophylaxis 4\u2005hours before SHIV exposure. Here, we show that the same inserts provide significant postexposure protection (82.9% efficacy) when applied 4 hours after SHIV exposure. Our findings further support the ongoing clinical development of TAF\/EVG inserts for on-demand HIV prevention.<\/jats:p>","DOI":"10.1093\/infdis\/jiaf611","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:07:55Z","timestamp":1764767275000},"page":"e932-e936","source":"Crossref","is-referenced-by-count":1,"title":["Partial Post-exposure Protection by Topical Inserts Containing Tenofovir Alafenamide Fumarate\/Elvitegravir in a Macaque Model of Rectal Simian HIV (SHIV) Infection"],"prefix":"10.1093","volume":"233","author":[{"given":"Natalia","family":"Makarova","sequence":"first","affiliation":[{"name":"Laboratory Branch, Division of HIV Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia 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for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Branch, Division of HIV Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Heneine","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of HIV Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-8287","authenticated-orcid":false,"given":"Meredith R","family":"Clark","sequence":"additional","affiliation":[{"name":"CONRAD, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University , Norfolk, Virginia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-7745","authenticated-orcid":false,"given":"J Gerardo","family":"Garc\u00eda-Lerma","sequence":"additional","affiliation":[{"name":"Laboratory Branch, Division of HIV Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo F","family":"Doncel","sequence":"additional","affiliation":[{"name":"CONRAD, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University , Norfolk, Virginia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M","family":"Smith","sequence":"additional","affiliation":[{"name":"Laboratory 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