{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:18:34Z","timestamp":1777774714092,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European-Latin American ESCALON"},{"DOI":"10.13039\/501100000780","name":"European Union Horizon","doi-asserted-by":"publisher","award":["825510"],"award-info":[{"award-number":["825510"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003033","name":"Ministry of Science, Technology and Innovation of Argentina","doi-asserted-by":"publisher","award":["PICT 2019\u201302222"],"award-info":[{"award-number":["PICT 2019\u201302222"]}],"id":[{"id":"10.13039\/501100003033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21TW012390-01A1"],"award-info":[{"award-number":["R21TW012390-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretariat of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010442","name":"National University of C\u00f3rdoba","doi-asserted-by":"publisher","award":["Consolidar-PIP-33620230100187-CB"],"award-info":[{"award-number":["Consolidar-PIP-33620230100187-CB"]}],"id":[{"id":"10.13039\/100010442","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide, yet its impact in Latin America remains underexplored. Evidence suggests that chronic liver disease (CLD) patients infected with HEV face increased risks of disease progression and mortality. The PROGINS haplotype has been proposed to influence susceptibility to HEV. This study assessed HEV infection in CLD patients from Latin America and potential associated factors, including the PROGINS haplotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 971 individuals\u2014784 with CLD and 187 healthy controls (HC)\u2014from six countries (Argentina, Brazil, Chile, Colombia, Ecuador, and Peru) were analyzed for anti-HEV IgG and IgM (ELISA), HEV-RNA (RT-qPCR and nested PCR with Sanger sequencing and phylogenetic analysis), and the PROGINS haplotype (PCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall anti-HEV IgG seroprevalence was 15.2%: 15.4% in CLD and 14.4% in HC, with no statistical difference. Marked geographical disparities were observed, with Chile showing the highest (45.1%) and Argentina the lowest (4.2%) anti-HEV IgG detection rates. Cirrhosis and alcohol-related liver disease (ALD) were significantly associated with higher detection rates, while neither age nor sex influenced HEV seroprevalences. PROGINS haplotype showed no significant association with HEV infection. Anti-HEV IgM and HEV-RNA were detected in 11.2% and 0.4% of participants, respectively. Phylogenetic analysis confirmed zoonotic HEV-3 circulation in the region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This first multinational assessment of HEV in Latin America reveals heterogeneous seroprevalence across countries. Findings support considering HEV testing in diagnostic protocols for CLD patients particularly those with cirrhosis or ALD- when presenting with unexplained hepatic decompensation or acute hepatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaf615","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:27:29Z","timestamp":1768307249000},"page":"e1046-e1055","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis E Virus Infection in Patients With Chronic Liver Diseases: A Latin American Multicenter Study"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-4116","authenticated-orcid":false,"given":"Anabella Clara","family":"Fantilli","sequence":"first","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas, Instituto de Virolog\u00eda \u201cDr. J.M. Vanella\u201d, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba ,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0336-3750","authenticated-orcid":false,"given":"Mar\u00eda Bel\u00e9n","family":"Pisano","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas, Instituto de Virolog\u00eda \u201cDr. J.M. Vanella\u201d, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba ,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Mart\u00ednez Wassaf","sequence":"additional","affiliation":[{"name":"Departamento de Virolog\u00eda, LACE laboratorios, C\u00f3rdoba ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9349-6441","authenticated-orcid":false,"given":"Guadalupe","family":"Di Cola","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas, Instituto de Virolog\u00eda \u201cDr. J.M. Vanella\u201d, Universidad Nacional de C\u00f3rdoba , C\u00f3rdoba ,","place":["Argentina"]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Buenos Aires ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo","family":"Balderramo","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba , C\u00f3rdoba ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-9070","authenticated-orcid":false,"given":"Pablo","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) , Buenos Aires ,","place":["Argentina"]},{"name":"Hospital Privado Universitario de C\u00f3rdoba , C\u00f3rdoba ,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-5999","authenticated-orcid":false,"given":"Jhon","family":"Prieto","sequence":"additional","affiliation":[{"name":"Centro de Enfermedades Hep\u00e1ticas y Digestivas (CEHYD) , Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Arrese","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile , Santiago ,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-8629","authenticated-orcid":false,"given":"Enrique","family":"Carrera","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda y Hepatolog\u00eda, Hospital Especialidades Eugenio Espejo, Universidad San Francisco de Quito , Quito 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