{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:13:06Z","timestamp":1788369186683,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"African Higher Education Centers of Excellence project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malaria remains a major health challenge in sub-Saharan Africa. Host genetic variation influences susceptibility, but the contribution of inhibitory receptors such as LILRB1\u2014targeted by Plasmodium falciparum RIFINs\u2014remains poorly defined. We investigated whether regulatory variants in LILRB1 modulate malaria risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Regulatory variants were prioritized from African expression quantitative trait locus (eQTL) datasets by integrating linkage disequilibrium, chromatin accessibility, and transcription factor binding. Three noncoding variants (rs10416697, rs10423364, and rs7246537) and one coding variant (rs1061680) were selected. Genotyping was performed in 267 Senegalese individuals with malaria or healthy status. Logistic regression adjusted for age assessed genetic associations. The functional effect of rs7246537 was evaluated using luciferase reporter assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-nine variants were associated with LILRB1 expression in African populations, three overlapping open chromatin near the distal promoter. Only rs7246537 showed significant association with malaria. Carriers of the A allele had reduced risk of clinical malaria and cerebral malaria. rs7246537 colocalized with a YY1-binding site, and luciferase assays demonstrated allele-specific effects, with the A allele driving lower promoter activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>rs7246537 is a functional regulatory variant that reduces malaria susceptibility by modulating LILRB1 expression, highlighting the role of noncoding variation in malaria pathogenesis. These findings support inhibitory immune pathways as important determinants of malaria outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag007","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:24:43Z","timestamp":1767443083000},"page":"267-276","source":"Crossref","is-referenced-by-count":0,"title":["A Functional Intronic Variant of\n                    <i>LILRB1<\/i>\n                    Associated With Clinical Malaria in the Senegalese Population"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3567-1301","authenticated-orcid":false,"given":"Christelle","family":"Dieppois","sequence":"first","affiliation":[{"name":"Aix-Marseille Univ, INSERM, TAGC, UMR 1090, MarMaRa Institute , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-2089","authenticated-orcid":false,"given":"Gael","family":"Chambonnier","sequence":"additional","affiliation":[{"name":"Aix-Marseille Univ, INSERM, TAGC, UMR 1090, MarMaRa Institute , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Aix-Marseille Univ, INSERM, TAGC, UMR 1090, MarMaRa Institute , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Torres","sequence":"additional","affiliation":[{"name":"Aix-Marseille Univ, INSERM, TAGC, UMR 1090, MarMaRa Institute , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alassane","family":"Thiam","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Dakar , Pole Immunophysiopathologie et Maladies Infectieuses (IMI), Unit\u00e9 Immunog\u00e9n\u00e9tique, Dakar ,","place":["S\u00e9n\u00e9gal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babacar","family":"Mbengue","sequence":"additional","affiliation":[{"name":"Immunology Departement, Universit\u00e9 Cheikh Anta Diop de Dakar , Dakar ,","place":["S\u00e9n\u00e9gal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alioune","family":"Dieye","sequence":"additional","affiliation":[{"name":"Immunology Departement, Universit\u00e9 Cheikh Anta Diop de Dakar , Dakar ,","place":["S\u00e9n\u00e9gal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-3905","authenticated-orcid":false,"given":"Pascal","family":"Rihet","sequence":"additional","affiliation":[{"name":"Aix-Marseille Univ, INSERM, TAGC, UMR 1090, MarMaRa Institute , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-4479","authenticated-orcid":false,"given":"Pascale","family":"Paul","sequence":"additional","affiliation":[{"name":"Aix-Marseille Univ, INSERM, TAGC, UMR 1090, MarMaRa Institute , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"2026090212203468400_jiag007-B1","doi-asserted-by":"crossref","first-page":"101073","DOI":"10.1016\/j.lanmic.2025.101073","article-title":"WHO world malaria report 2024","volume":"6","author":"Venkatesan","year":"2025","journal-title":"Lancet Microbe"},{"key":"2026090212203468400_jiag007-B2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12936-022-04301-8","article-title":"Severe malaria","volume":"21","author":"White","year":"2022","journal-title":"Malar J"},{"key":"2026090212203468400_jiag007-B3","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/S0140-6736(97)02038-2","article-title":"Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa","volume":"349","author":"Snow","year":"1997","journal-title":"Lancet Lond Engl"},{"key":"2026090212203468400_jiag007-B4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00439-020-02142-6","article-title":"Human genetics and malaria resistance","volume":"139","author":"Kariuki","year":"2020","journal-title":"Hum Genet"},{"key":"2026090212203468400_jiag007-B5","doi-asserted-by":"crossref","first-page":"12062","DOI":"10.1038\/s41598-023-39233-z","article-title":"High throughput human genotyping for variants associated with malarial disease outcomes using custom targeted amplicon sequencing","volume":"13","author":"Osborne","year":"2023","journal-title":"Sci Rep"},{"key":"2026090212203468400_jiag007-B6","doi-asserted-by":"crossref","unstructured":"Damena D, Agamah FE, Kimathi PO, et al \u00a0In silico functional analysis of genome-wide dataset from 17,000 individuals identifies candidate malaria resistance genes enriched in malaria pathogenic pathways. 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