{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:12:51Z","timestamp":1788369171774,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"crossref","award":["E-26\/210.666\/2021"],"award-info":[{"award-number":["E-26\/210.666\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto Nacional de Infectologia Evandro Chagas","award":["VPPCB-005-FIO-21-2-18"],"award-info":[{"award-number":["VPPCB-005-FIO-21-2-18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chagas disease (ChD), a major public health concern in Latin America, requires better understanding of molecular mechanisms driving disease progression and identification of biomarkers. We investigated circulating microRNAs associated with ChD susceptibility and chronic Chagas cardiomyopathy (CCC) progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cross-sectional study of 150 patients with ChD (46 indeterminate, 104 CCC) and 42 non-ChD controls, we performed microRNA sequencing, and differentiated expressed microRNAs (DEMs) were submitted to in silico functional analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 40 DEMs between patients with ChD and controls, highlighting upregulated miR-143-3p and miR-223-3p, and downregulated miR-486-5p and miR-3960 in patients with ChD. These miRNAs showed involvement in immune response and cardiovascular signaling pathways. MiR-6734-5p, miR-1285-5p, miR-10527-5p, and miR-1228-5p tended to be upregulated, while miR-30c-3p tended to be downregulated in patients with severe compared to mild CCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides evidence for specific microRNA dysregulation in ChD, highlighting their potential as biomarkers of ChD susceptibility and CCC severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag021","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:43:41Z","timestamp":1768481021000},"page":"277-287","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptome Analysis of Circulating microRNAs Associated With Chagas Disease Susceptibility and Chronic Chagas Cardiomyopathy Severity"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-5277","authenticated-orcid":false,"given":"Eric Henrique","family":"Roma","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Imunogen\u00e9tica em Doen\u00e7as Infeciosas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1422-4833","authenticated-orcid":false,"given":"Fabielle","family":"Marques-Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Imunogen\u00e9tica em Doen\u00e7as Infeciosas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]},{"name":"Laborat\u00f3rio de Pesquisa Cl\u00ednica em Doen\u00e7a de Chagas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alinne Rangel dos Santos","family":"Renzetti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Imunogen\u00e9tica em Doen\u00e7as Infeciosas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]},{"name":"Laborat\u00f3rio de Pesquisa Cl\u00ednica em Doen\u00e7a de Chagas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8961-468X","authenticated-orcid":false,"given":"Luciana Fernandes","family":"Portela","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa Cl\u00ednica em Doen\u00e7a de Chagas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-689X","authenticated-orcid":false,"given":"Filipe Pereira","family":"da Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia e Imunogen\u00e9tica em Doen\u00e7as Infeciosas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]},{"name":"Laborat\u00f3rio de Pesquisa Cl\u00ednica em Doen\u00e7a de Chagas, Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz , Rio de Janeiro ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-7222","authenticated-orcid":false,"given":"Alejandro Marcel","family":"Hasslocher-Moreno","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa Cl\u00ednica em Doen\u00e7a de Chagas, Instituto Nacional de Infectologia 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