{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:34:33Z","timestamp":1791005673697,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute for Nursing Research","doi-asserted-by":"publisher","award":["R01NR012907, R01NR014449, R01NR012657, and R01NR015738 to B. M. A."],"award-info":[{"award-number":["R01NR012907, R01NR014449, R01NR012657, and R01NR015738 to B. M. A."]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH118031 to B. M. A."],"award-info":[{"award-number":["R01MH118031 to B. M. A."]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This study analyzed the effects of aging, HIV serostatus, and viral load on cognition and brain volumes in a large cohort of persons without HIV (PWOH), PWH with undetectable virus (PWHU) (HIV RNA \u226450 copies\/mL), and PWH with detectable virus (PHWD) (HIV RNA &amp;gt;50 copies\/mL). Cross-sectional and longitudinal data were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cognitive composites (NPZ4) and brain volumes were obtained from 259 PWOH, 264 PWHU, and 84 PWHD with a total of 841 sessions. A series of generalized additive mixed models explored group differences in the relationship between age and cognition, age and regional brain volumes, and interactions between age and brain volumes on cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PWOH and PWHU exhibited similar change in cognitive performance with age, while PWHD exhibited a steeper decline compared to both. While both PWH groups had significantly smaller regional brain volumes compared to PWOH, the slopes of volume loss with age were similar across all groups except in the lentiform regions. Smaller brain volumes and increased age interacted for greater cognitive decline in PWHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PWH who achieve viral suppression do not exhibit accelerated decline in cognition or brain volumes compared to PWOH, while PWHD may be at an increased risk for accelerated cognitive decline. These findings highlight the clinical importance of managing viral load in aging PWH and suggest that once viral suppression is achieved, changes to brain integrity are not accelerated compared to PWOH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag029","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:27:42Z","timestamp":1768307262000},"page":"e1173-e1180","source":"Crossref","is-referenced-by-count":3,"title":["Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus"],"prefix":"10.1093","volume":"233","author":[{"given":"James","family":"Kennedy","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-241X","authenticated-orcid":false,"given":"Sarah A","family":"Cooley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Roman Fox","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-9648","authenticated-orcid":false,"given":"Kalen J","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Westerhaus","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7549-2081","authenticated-orcid":false,"given":"Linet","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau M","family":"Ances","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]},{"name":"Department of Radiology, Washington University School of Medicine , St Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"2026051419581484000_jiag029-B1","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1016\/S2352-3018(23)00028-0","article-title":"Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies","volume":"10","author":"Trickey","year":"2023","journal-title":"Lancet HIV"},{"key":"2026051419581484000_jiag029-B2","author":"Centers for Disease Control and Prevention"},{"key":"2026051419581484000_jiag029-B3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13365-010-0006-1","article-title":"HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors","volume":"17","author":"Heaton","year":"2011","journal-title":"J. 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