{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:36:31Z","timestamp":1792143391698,"version":"4.4.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 AI068634"],"award-info":[{"award-number":["UM1 AI068634"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 AI068636"],"award-info":[{"award-number":["UM1 AI068636"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 AI106701"],"award-info":[{"award-number":["UM1 AI106701"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006392","name":"New Works Concept Sheet (NWCS) 526 from the Advancing Clinical Therapeutics Globally for HIV\/AIDS and Other Infections (ACTG) network","doi-asserted-by":"publisher","award":["AI068636"],"award-info":[{"award-number":["AI068636"]}],"id":[{"id":"10.13039\/100006392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24 AG082527"],"award-info":[{"award-number":["K24 AG082527"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Veterans Affairs Merit Award","doi-asserted-by":"publisher","award":["BX006011"],"award-info":[{"award-number":["BX006011"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about the specific inflammatory networks and immune parameters that drive frailty outcomes in people with HIV (PWH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma analytes and T-cell phenotypes from PWH without frailty (0 Fried score, n = 60) and with frailty (\u22653 Fried score, n = 60) were measured by Luminex assay or flow cytometry. Multiple least-squares linear regression analysis was used to determine the association of each marker with frailty in unadjusted and adjusted models. Spearman correlations were used to determine the association of plasma analytes with T-cell phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that 19 of 75 markers measured in plasma were significantly associated with frailty, most of which are downstream of NF-\u03baB signaling and are senescence-associated secretory phenotype (SASP) components. In frail individuals, the proportions of CD4 and CD8 T cells with a na\u00efve phenotype were significantly reduced, and the proportions of CD4 T cells expressing TIGIT and PD-1 were significantly elevated. Of the frailty-associated analytes, we found that only osteoprotegerin and TNF levels were significantly correlated with percent na\u00efve, TIGIT+, and PD-1+ CD4 T cells among PWH with frailty. Osteoprotegerin levels were negatively correlated with CD4\/CD8 T-cell ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found a strong association of the SASP and NF-\u03baB-related inflammation with frailty in PWH. Osteoprotegerin can inhibit osteoclast formation and prevent bone resorption. Low proportion of na\u00efve CD4 T cells and increased TIGIT and PD-1 expression were associated with both osteoprotegerin levels and frailty, suggesting a link between inflammation, T-cell activation, bone health, and frailty in PWH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag046","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:57:25Z","timestamp":1769086645000},"page":"995-1004","source":"Crossref","is-referenced-by-count":4,"title":["Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-5258","authenticated-orcid":false,"given":"Michael L","family":"Freeman","sequence":"first","affiliation":[{"name":"Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]},{"name":"Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-8250","authenticated-orcid":false,"given":"Wendy","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Section on Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4046-125X","authenticated-orcid":false,"given":"Brian M","family":"Clagett","sequence":"additional","affiliation":[{"name":"Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3380-2527","authenticated-orcid":false,"given":"Katelyn A","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3999-1023","authenticated-orcid":false,"given":"Vikhyath","family":"Jonnalagadda","sequence":"additional","affiliation":[{"name":"Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid M","family":"Wilson","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center, Veterans Affairs Northeast Ohio Healthcare System , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Margolis","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences and Medicine, Ilia State University , Tbilisi ,","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunling","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-2535","authenticated-orcid":false,"given":"Katherine","family":"Tassiopoulos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey L","family":"Shive","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center, Veterans Affairs Northeast Ohio Healthcare System , Cleveland, Ohio ,","place":["USA"]},{"name":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-6729","authenticated-orcid":false,"given":"Kristine M","family":"Erlandson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"2026061615195129300_jiag046-B1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11904-021-00547-0","article-title":"Probing the interface of HIV and inflammaging","volume":"18","author":"Sieg","year":"2021","journal-title":"Curr HIV\/AIDS Rep"},{"key":"2026061615195129300_jiag046-B2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11904-019-00464-3","article-title":"Aging with HIV","volume":"16","author":"Guaraldi","year":"2019","journal-title":"Curr HIV\/AIDS Rep"},{"key":"2026061615195129300_jiag046-B3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cytogfr.2021.01.006","article-title":"Hallmarks of aging and immunosenescence: connecting the dots","volume":"59","author":"Rodrigues","year":"2021","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026061615195129300_jiag046-B4","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/infdis\/jiu254","article-title":"Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment","volume":"210","author":"Tenorio","year":"2014","journal-title":"J Infect Dis"},{"key":"2026061615195129300_jiag046-B5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/QAI.0000000000001261","article-title":"Frailty and circulating markers of inflammation in HIV+ and HIV- men in the multicenter AIDS cohort study","volume":"74","author":"Margolick","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026061615195129300_jiag046-B6","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/infdis\/jiu238","article-title":"Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection","volume":"210","author":"Hunt","year":"2014","journal-title":"J Infect Dis"},{"key":"2026061615195129300_jiag046-B7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1474-9726.2009.00489.x","article-title":"Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging","volume":"8","author":"Liu","year":"2009","journal-title":"Aging Cell"},{"key":"2026061615195129300_jiag046-B8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40001-017-0266-9","article-title":"A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-alpha","volume":"22","author":"Bian","year":"2017","journal-title":"Eur J Med Res"},{"key":"2026061615195129300_jiag046-B9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1742-4933-10-33","article-title":"Seropositivity for CMV and IL-6 levels are associated with grip strength and muscle size in the elderly","volume":"10","author":"Kilgour","year":"2013","journal-title":"Immun Ageing"},{"key":"2026061615195129300_jiag046-B10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.mad.2006.04.003","article-title":"The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning","volume":"127","author":"Wikby","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"2026061615195129300_jiag046-B11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/gerona\/61.6.575","article-title":"Interleukin-6 in aging and chronic disease: a magnificent pathway","volume":"61","author":"Maggio","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026061615195129300_jiag046-B12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11357-021-00343-z","article-title":"IL-6 can singlehandedly drive many features of frailty in mice","volume":"43","author":"Jergovic","year":"2021","journal-title":"Geroscience"},{"key":"2026061615195129300_jiag046-B13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/cid\/ciad199","article-title":"Interleukin 6 blockade with tocilizumab diminishes indices of inflammation that are linked to mortality in treated human immunodeficiency virus infection","volume":"77","author":"Funderburg","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2026061615195129300_jiag046-B14","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1097\/QAD.0000000000001613","article-title":"Frailty is strongly associated with increased risk of recurrent falls among older HIV-infected adults","volume":"31","author":"Tassiopoulos","year":"2017","journal-title":"AIDS"},{"key":"2026061615195129300_jiag046-B15","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/infdis\/jix063","article-title":"Association between frailty and components of the frailty phenotype with modifiable risk factors and antiretroviral therapy","volume":"215","author":"Erlandson","year":"2017","journal-title":"J Infect Dis"},{"key":"2026061615195129300_jiag046-B16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/QAD.0000000000004086","article-title":"Predictors of frailty trajectories among people with HIV","volume":"39","author":"Iriarte","year":"2024","journal-title":"AIDS"},{"key":"2026061615195129300_jiag046-B17","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026061615195129300_jiag046-B18","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1038\/s41598-018-27190-x","article-title":"A system of cytokines encapsulated in extracellular vesicles","volume":"8","author":"Fitzgerald","year":"2018","journal-title":"Sci Rep"},{"key":"2026061615195129300_jiag046-B19","doi-asserted-by":"crossref","first-page":"2177529","DOI":"10.1080\/14767058.2023.2177529","article-title":"Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death","volume":"36","author":"Gallo","year":"2023","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"D1","key":"2026061615195129300_jiag046-B20","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"2026061615195129300_jiag046-B21","doi-asserted-by":"crossref","first-page":"D380","DOI":"10.1093\/nar\/gkx1013","article-title":"TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions","volume":"46","author":"Han","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2026061615195129300_jiag046-B22","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Coppe","year":"2008","journal-title":"PLoS Biol"},{"key":"2026061615195129300_jiag046-B23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10555-010-9220-9","article-title":"Senescent cells as a source of inflammatory factors for tumor progression","volume":"29","author":"Davalos","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"2026061615195129300_jiag046-B24","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat Cell Biol"},{"key":"2026061615195129300_jiag046-B25","doi-asserted-by":"crossref","first-page":"e133668","DOI":"10.1172\/jci.insight.133668","article-title":"The senescence-associated secretome as an indicator of age and medical risk","volume":"5","author":"Schafer","year":"2020","journal-title":"JCI Insight"},{"key":"2026061615195129300_jiag046-B26","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41374-021-00629-y","article-title":"Th17\/IL-17 induces endothelial cell senescence via activation of NF-kappaB\/p53\/Rb signaling pathway","volume":"101","author":"Zhang","year":"2021","journal-title":"Lab Invest"},{"key":"2026061615195129300_jiag046-B27","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1038\/s41467-022-31642-4","article-title":"Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells","volume":"13","author":"Igarashi","year":"2022","journal-title":"Nat Commun"},{"key":"2026061615195129300_jiag046-B28","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3390\/cells13191613","article-title":"Senescence biomarkers CKAP4 and PTX3 stratify severe kidney disease patients","volume":"13","author":"McCallion","year":"2024","journal-title":"Cells"},{"key":"2026061615195129300_jiag046-B29","doi-asserted-by":"crossref","first-page":"151438","DOI":"10.1016\/j.ejcb.2024.151438","article-title":"Alterations of receptors and insulin-like growth factor binding proteins in senescent cells","volume":"103","author":"Matuszewska","year":"2024","journal-title":"Eur J Cell Biol"},{"key":"2026061615195129300_jiag046-B30","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1002\/stem.1654","article-title":"Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model","volume":"32","author":"Sepulveda","year":"2014","journal-title":"Stem Cells"},{"key":"2026061615195129300_jiag046-B31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v048.i04","article-title":"Qgraph: network visualizations of relationships in psychometric data","volume":"48","author":"Epskamp","year":"2012","journal-title":"J Stat Softw"},{"key":"2026061615195129300_jiag046-B32","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1097\/QAD.0000000000003954","article-title":"Association between switching to integrase strand transfer inhibitors and incident diabetes in people with HIV","volume":"38","author":"Hwang","year":"2024","journal-title":"AIDS"},{"key":"2026061615195129300_jiag046-B33","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026061615195129300_jiag046-B34","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s11357-012-9400-3","article-title":"The inverted CD4\/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study","volume":"35","author":"Strindhall","year":"2013","journal-title":"Age (Dordr)"},{"key":"2026061615195129300_jiag046-B35","doi-asserted-by":"crossref","first-page":"e1004078","DOI":"10.1371\/journal.ppat.1004078","article-title":"HIV-infected individuals with low CD4\/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality","volume":"10","author":"Serrano-Villar","year":"2014","journal-title":"PLoS Pathog"},{"key":"2026061615195129300_jiag046-B36","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1182\/blood-2002-07-2103","article-title":"Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells","volume":"101","author":"Brenchley","year":"2003","journal-title":"Blood"},{"key":"2026061615195129300_jiag046-B37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.onc.1201965","article-title":"Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence","volume":"17","author":"Erickson","year":"1998","journal-title":"Oncogene"},{"key":"2026061615195129300_jiag046-B38","doi-asserted-by":"crossref","first-page":"132963","DOI":"10.1172\/jci.insight.132963","article-title":"Inflammescent CX3CR1+CD57+CD8+ T cells are generated and expanded by IL-15","volume":"5","author":"Morris","year":"2020","journal-title":"JCI Insight"},{"key":"2026061615195129300_jiag046-B39","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1038\/s41467-019-13139-9","article-title":"A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension","volume":"10","author":"Arnold","year":"2019","journal-title":"Nat Commun"},{"key":"2026061615195129300_jiag046-B40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"2026061615195129300_jiag046-B41","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.18632\/aging.102083","article-title":"Osteoprotegerin as a biomarker of geriatric frailty syndrome","volume":"11","author":"Valentini","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"2026061615195129300_jiag046-B42","first-page":"192594","article-title":"Immune activation, immunosenescence, and osteoprotegerin as markers of endothelial dysfunction in subclinical HIV-associated atherosclerosis","volume":"2014","author":"D'Abramo","year":"2014","journal-title":"Mediators Inflamm"},{"key":"2026061615195129300_jiag046-B43","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/QAI.0000000000000725","article-title":"Osteoprotegerin, but not receptor activator for nuclear factor-kappaB ligand, is associated with subclinical coronary atherosclerosis in HIV-infected men","volume":"70","author":"Ketlogetswe","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2026061615195129300_jiag046-B44","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.4049\/jimmunol.162.5.2562","article-title":"TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells","volume":"162","author":"Josien","year":"1999","journal-title":"J Immunol"},{"key":"2026061615195129300_jiag046-B45","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.celrep.2017.10.111","article-title":"Receptor activator of NF-kappaB orchestrates activation of antiviral memory CD8 T cells in the spleen marginal zone","volume":"21","author":"Habbeddine","year":"2017","journal-title":"Cell Rep"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag046\/66789366\/jiag046.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/233\/6\/995\/66789366\/jiag046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/233\/6\/995\/66789366\/jiag046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:20:04Z","timestamp":1781637604000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/233\/6\/995\/8465467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,2,6]]},"published-print":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiag046","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6,15]]},"published":{"date-parts":[[2026,2,6]]}}}