{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:35:36Z","timestamp":1791898536574,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-dose dual therapy (HDDT) is a promising first-line treatment option for Helicobacter pylori infection. In this study, we aimed to compare the efficacy and safety of different HDDT regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study included data from 10 centers between January 2022 and January 2025. Inverse probability of treatment-weighted (IPTW) adjustment was used to address the imbalance in variables across groups. The outcomes included the eradication rate, adverse events, and adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1665 patients were included, with a full analysis set (FAS) eradication rate of 88.6% and a per-protocol (PP) eradication rate of 89.5% for HDDT. After IPTW adjustment, the eradication rate of vonoprazan\u2013amoxicillin (VA) 14-day based on FAS analysis was 95.1%, which was significantly higher than VA-10 day (88.7%) (P = .001), esomeprazole\u2013amoxicillin (EA) (85.1%) (P &amp;lt; .001), and tegoprazan\u2013amoxicillin (TA) (87.3%) (P &amp;lt; .001). The incidence of adverse events for VA-14 was 8.1%, which was comparable to VA-10 (11.1%) but lower than TA (14.4%) and EA (15.3%) (P = .002). Adherence showed no significant difference across groups. High body surface area (BSA) (\u22651.80 m\u00b2) (OR 1.594, 95% confidence interval [CI], 1.018\u20132.495, P = .041), poor adherence (OR 4.975, 95% CI, 2.753\u20138.992, P &amp;lt; .001), and non-VA-14 treatment regimen were independent risk factors for eradication failure. Factors varied across regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HDDT, particularly VA-14, is a competitive first-line option for H. pylori eradication. High BSA and low adherence were risk factors for eradication failure but varied across regimens, highlighting the necessity of personalized adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag059","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:42:56Z","timestamp":1769690576000},"page":"966-974","source":"Crossref","is-referenced-by-count":5,"title":["Comparative Analysis of High-Dose Dual Therapies in First-Line\n                    <i>Helicobacter pylori<\/i>\n                    Eradication: An Inverse Probability of Treatment-Weighted Multicenter Study"],"prefix":"10.1093","volume":"233","author":[{"given":"Qingzhou","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University , Jinan, Shandong ,","place":["China"]},{"name":"Laboratory of Translational Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University , Jinan, Shandong ,","place":["China"]},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease, Qilu Hospital of Shandong University , Jinan, Shandong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baobao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University , Jinan, Shandong ,","place":["China"]},{"name":"Laboratory of Translational Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University , Jinan, Shandong ,","place":["China"]},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease, Qilu Hospital of Shandong University , Jinan, Shandong 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