{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:11:56Z","timestamp":1778803916754,"version":"3.51.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite transformative advances in antiretroviral therapy, human immunodeficiency virus (HIV) remains a lifelong condition driven by durable viral reservoirs, chronic immune dysfunction, and complex interactions with host biology, coinfections, and aging. While implementation science is essential to ensure that effective interventions reach populations most affected by HIV, implementation cannot succeed in isolation from continued discovery or from the political and social contexts in which care is delivered. This editorial highlights critical gaps in our understanding of sex-based immunologic differences, tissue-specific viral persistence, resistance evolution, and the long-term inflammatory and metabolic consequences of treated HIV\u2014gaps that directly constrain the durability, equity, and scalability of prevention, treatment, and cure strategies. We further emphasize that successful translation depends on stable policy environments, sustained public investment, and trust-based partnerships with affected communities, without which even highly effective biomedical advances fail to achieve impact. Sustained investment across the full translational spectrum\u2014from basic and mechanistic science through clinical, behavioral, and implementation research\u2014is therefore essential. HIV research has repeatedly served as a model system driving advances across immunology, vaccinology, oncology, aging, and pandemic preparedness, underscoring its broader relevance to human infectious diseases.<\/jats:p>","DOI":"10.1093\/infdis\/jiag063","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:46:06Z","timestamp":1769777166000},"page":"e1085-e1087","source":"Crossref","is-referenced-by-count":0,"title":["Implementation Does Not Occur in a Vacuum: Sustaining a Comprehensive and Global Vision for HIV Research"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-0849","authenticated-orcid":false,"given":"Sara","family":"Gianella","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, UC San Diego , La Jolla, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-8335","authenticated-orcid":false,"given":"Adam S","family":"Lauring","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School , Ann Arbor, Michigan ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-691X","authenticated-orcid":false,"given":"Roger","family":"Paredes","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Germans Trias I Pujol; IrsiCaixa AIDS Research Institute , Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-6825","authenticated-orcid":false,"given":"Julio","family":"Croda","sequence":"additional","affiliation":[{"name":"Fiocruz Mato Grosso do Sul (Funda\u00e7\u00e3o Oswaldo Cruz) , Campo Grande, Mato Grosso do Sul ,","place":["Brazil"]},{"name":"Faculty of Medicine, Universidade Federal de Mato Grosso do Sul , Campo Grande ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-9950","authenticated-orcid":false,"given":"David","family":"Andes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Departments of Medicine and Medical Microbiology & Immunology, University of Wisconsin\u2013Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-4768","authenticated-orcid":false,"given":"Anne-Catrin","family":"Uhlemann","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Columbia University Irving Medical Center , NewYork, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara W","family":"Chew","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Center for Clinical AIDS Research & Education (CARE), David Geffen School of Medicine at UCLA , Los Angeles, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3440-4105","authenticated-orcid":false,"given":"Kathryn E","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A","family":"Lewnard","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-8537","authenticated-orcid":false,"given":"Audrey R","family":"Odom John","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania , Philadelphia Pennsylvania ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8401-0801","authenticated-orcid":false,"given":"Daniel T","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius J","family":"Clancy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh , Pittsburgh, Pennsylvania 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