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How sex impacts viral reservoirs in macaques is unknown. We sought to uncover potential sex differences in viral measurements during antiretroviral therapy using data from 19 studies conducted at Emory Primate Center. Sex differences in total and intact SIV\/SHIV-DNA levels in blood and lymph node CD4+ T cells were not observed, although subgroup analysis of adult macaques with SIV revealed higher reservoir levels in females. Age (adult versus infant) was a significant effect for all viral outcomes studied.<\/jats:p>","DOI":"10.1093\/infdis\/jiag064","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:41:02Z","timestamp":1769776862000},"page":"e1418-e1422","source":"Crossref","is-referenced-by-count":0,"title":["Limited Sex-Based Differences in Viral Outcomes of ART-Treated SIV\/SHIV Infection"],"prefix":"10.1093","volume":"233","author":[{"given":"Kedan","family":"Endrias","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Sonawane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia 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,","place":["USA"]},{"name":"Emory National Primate Research Center, Emory University , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Paiardini","sequence":"additional","affiliation":[{"name":"Emory Center for AIDS Research, Emory University , Atlanta, Georgia ,","place":["USA"]},{"name":"Emory National Primate Research Center, Emory University , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-2470","authenticated-orcid":false,"given":"Guido","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Emory Center for AIDS Research, Emory University , Atlanta, Georgia ,","place":["USA"]},{"name":"Emory National Primate Research Center, Emory University , Atlanta, Georgia 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therapy","volume":"69","author":"Fourati","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"2026061615192144700_jiag064-B5","doi-asserted-by":"crossref","first-page":"e1006285","DOI":"10.1371\/journal.ppat.1006285","article-title":"Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation","volume":"13","author":"Gandhi","year":"2017","journal-title":"PLoS Pathog"},{"key":"2026061615192144700_jiag064-B6","doi-asserted-by":"crossref","first-page":"e139287","DOI":"10.1172\/jci.insight.139287","article-title":"Reduced HIV-1 latent reservoir outgrowth and distinct immune correlates among women in Rakai, Uganda","volume":"5","author":"Prodger","year":"2020","journal-title":"JCI Insight"},{"key":"2026061615192144700_jiag064-B7","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/infdis\/jiy617","article-title":"Sex-based differences in human immunodeficiency virus type 1 reservoir activity and residual 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