{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:55:14Z","timestamp":1781639714215,"version":"3.54.5"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intermittent preventive treatment with monthly sulfadoxine-pyrimethamine (IPTp-SP) is recommended during pregnancy in malaria-endemic countries. However, widespread resistance of Plasmodium falciparum to SP has compromised its efficacy, and the alternative dihydroartemisinin-piperaquine (DP) is under study. Potential selection of drug resistance is important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We sequenced 1377 samples collected from pregnant women enrolled in a trial comparing monthly SP, DP, and DP + SP for IPTp in Busia, Uganda and with asymptomatic parasitemia at the time of IPTp administration. We characterized known markers of drug resistance and assessed the 28-day cumulative risk of recurrent parasitemia, with genotyping to distinguish recrudescence from new infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 771 samples collected on the day IPTp was initiated, the prevalences of 5 resistance mutations in P. falciparum dihydrofolate reductase (PfDHFR) and dihydropteroate synthase (PfDHPS) were nearly 100%, and the PfDHFR I164L and PfDHPS A581G mutations, associated with high-level resistance, had combined prevalence of 26.5%. The cumulative risks of recurrent parasitemia (SP 57.8%, DP 4.1%, DP + SP 3.9%), symptomatic malaria (SP 9.3%, DP 1.1%, DP + SP 0.3%), and recrudescent parasitemia (SP 40.1%, DP 2.0%, DP + SP 0.8%) were all significantly greater in the SP arm, with risks greatest in primigravidae. In the IPT-SP arm, the combined prevalence of the PfDHFR I164L and PfDHPS A581G mutations increased significantly from 24.9% at initiation of IPTp to 35.2% after receipt of IPTp-SP. Infection with mutant parasites was associated with non-significant increases in risks of recrudescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intermittent preventive treatment with monthly sulfadoxine-pyrimethamine had poor antimalarial preventive efficacy and selected for increased drug resistance, questioning the value of this intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag074","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:30:11Z","timestamp":1770726611000},"page":"1110-1119","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent\n                    <i>Plasmodium falciparum<\/i>\n                    Parasitemia and Drug Resistance Mutations During Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-4044","authenticated-orcid":false,"given":"Jimmy","family":"Kizza","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]},{"name":"Clinical Epidemiology Unit, Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-8911","authenticated-orcid":false,"given":"Thomas","family":"Katairo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Kakuru","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]},{"name":"Busitema University Department of Community and Public Health, , Tororo ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9786-7294","authenticated-orcid":false,"given":"Bienvenu","family":"Nsengimaana","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3265-7013","authenticated-orcid":false,"given":"Trevor","family":"Esilu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocent","family":"Wiringilimaana","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis D","family":"Semakuba","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-7473","authenticated-orcid":false,"given":"Inna","family":"Gerlovina","sequence":"additional","affiliation":[{"name":"University of California Department of Medicine, , SanFrancisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9639-2894","authenticated-orcid":false,"given":"Nicholas","family":"Hathaway","sequence":"additional","affiliation":[{"name":"University of California Department of Medicine, , SanFrancisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8078-3898","authenticated-orcid":false,"given":"Jessica","family":"Briggs","sequence":"additional","affiliation":[{"name":"University of California Department of Medicine, , SanFrancisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-6516","authenticated-orcid":false,"given":"Stephen","family":"Tukwasibwe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Kiwuwa","sequence":"additional","affiliation":[{"name":"Makerere University Department of Medicine, College of Health Sciences, , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses R","family":"Kamya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]},{"name":"Makerere University Department of Medicine, College of Health Sciences, , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaniter I","family":"Nankabirwa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration , Kampala ,","place":["Uganda"]},{"name":"Makerere University Department of Medicine, College of Health Sciences, , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-0317","authenticated-orcid":false,"given":"Grant","family":"Dorsey","sequence":"additional","affiliation":[{"name":"University of California Department of Medicine, , SanFrancisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"University of California Department of Medicine, , SanFrancisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"2026061615214341300_jiag074-B1","volume-title":"World malaria report 2025: addressing the threat of antimalarial drug resistance.","author":"WHO","year":"2025"},{"key":"2026061615214341300_jiag074-B2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/QCO.0000000000001037","article-title":"Malaria in pregnancy: baby steps","volume":"37","author":"Rogerson","year":"2024","journal-title":"Curr Opin Infect Dis"},{"key":"2026061615214341300_jiag074-B3","first-page":"Cd000169","article-title":"Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment","volume":"2014","author":"Radeva-Petrova","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2026061615214341300_jiag074-B4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1124\/pr.57.1.4","article-title":"Mechanisms of resistance of malaria parasites to antifolates","volume":"57","author":"Gregson","year":"2005","journal-title":"Pharmacol Rev"},{"key":"2026061615214341300_jiag074-B5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/cid\/civ881","article-title":"Impact of sulfadoxine-pyrimethamine resistance on effectiveness of intermittent preventive therapy for malaria in pregnancy at clearing infections and preventing low birth weight","volume":"62","author":"Desai","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2026061615214341300_jiag074-B6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.pt.2013.08.002","article-title":"Mapping \u2018partially resistant\u2019, \u2018fully resistant\u2019, and \u2018super resistant\u2019 malaria","volume":"29","author":"Naidoo","year":"2013","journal-title":"Trends Parasitol"},{"key":"2026061615214341300_jiag074-B7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12936-022-04115-8","article-title":"Malaria chemoprevention and drug resistance: a review of the literature and policy implications","volume":"21","author":"Plowe","year":"2022","journal-title":"Malar J"},{"key":"2026061615214341300_jiag074-B8","doi-asserted-by":"crossref","first-page":"e02029-19","DOI":"10.1128\/AAC.02029-19","article-title":"Effect of drug pressure on promoting the emergence of antimalarial-resistant parasites among pregnant women in Ghana","volume":"64","author":"Tornyigah","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2026061615214341300_jiag074-B9","doi-asserted-by":"crossref","first-page":"e01047-20","DOI":"10.1128\/AAC.01047-20","article-title":"Associations between malaria-preventive regimens and plasmodium falciparum drug resistance-mediating polymorphisms in Ugandan pregnant women","volume":"64","author":"Nayebare","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2026061615214341300_jiag074-B10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.pt.2013.07.008","article-title":"Monitoring antifolate resistance in intermittent preventive therapy for malaria","volume":"29","author":"Venkatesan","year":"2013","journal-title":"Trends Parasitol"},{"key":"2026061615214341300_jiag074-B11","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/infdis\/jiab117","article-title":"Reduced birth weight caused by sextuple drug-resistant plasmodium falciparum infection in early second trimester","volume":"224","author":"Hansson","year":"2021","journal-title":"J Infect Dis"},{"key":"2026061615214341300_jiag074-B12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/infdis\/jiaa145","article-title":"Interactions between antenatal sulfadoxine-pyrimethamine, drug-resistant plasmodium falciparum parasites, and delivery outcomes in Malawi","volume":"222","author":"Taylor","year":"2020","journal-title":"J Infect Dis"},{"key":"2026061615214341300_jiag074-B13","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/tmi.12595","article-title":"Influence of malaria transmission intensity and the 581G mutation on the efficacy of intermittent preventive treatment in pregnancy: systematic review and meta-analysis","volume":"20","author":"Chico","year":"2015","journal-title":"Trop Med Int Health"},{"key":"2026061615214341300_jiag074-B14","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S1473-3099(25)00219-1","article-title":"The impact of sulfadoxine-pyrimethamine resistance on the effectiveness of intermittent preventive treatment for the prevention of malaria in pregnancy in Africa: an updated systematic review and meta-analysis","volume":"25","author":"van Eijk","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"2026061615214341300_jiag074-B15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/cid\/cix026","article-title":"Sulfadoxine-pyrimethamine exhibits dose-response protection against adverse birth outcomes related to malaria and sexually transmitted and reproductive tract infections","volume":"64","author":"Chico","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2026061615214341300_jiag074-B16","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S0140-6736(22)02535-1","article-title":"Effect of monthly intermittent preventive treatment with dihydroartemisinin-piperaquine with and without azithromycin versus monthly sulfadoxine-pyrimethamine on adverse pregnancy outcomes in Africa: a double-blind randomised, partly placebo-controlled trial","volume":"401","author":"Madanitsa","year":"2023","journal-title":"Lancet"},{"key":"2026061615214341300_jiag074-B17","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0140-6736(18)32224-4","article-title":"Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial","volume":"393","author":"Kajubi","year":"2019","journal-title":"Lancet"},{"key":"2026061615214341300_jiag074-B18","doi-asserted-by":"crossref","first-page":"e1004582","DOI":"10.1371\/journal.pmed.1004582","article-title":"Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomized, controlled phase 3 trial from Uganda","volume":"22","author":"Kakuru","year":"2025","journal-title":"PLoS Med"},{"key":"2026061615214341300_jiag074-B19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/QCO.0000000000000766","article-title":"Artemisinin and multidrug-resistant Plasmodium falciparum\u2014a threat for malaria control and elimination","volume":"34","author":"Dhorda","year":"2021","journal-title":"Curr Opin Infect Dis"},{"key":"2026061615214341300_jiag074-B20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41579-024-01008-2","article-title":"Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa","volume":"22","author":"Rosenthal","year":"2024","journal-title":"Nat Rev Microbiol"},{"key":"2026061615214341300_jiag074-B21","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/infdis\/jiaa687","article-title":"Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda","volume":"223","author":"Asua","year":"2021","journal-title":"J Infect Dis"},{"key":"2026061615214341300_jiag074-B22","doi-asserted-by":"crossref","first-page":"102193","DOI":"10.1016\/j.mib.2022.102193","article-title":"Plasmodium falciparum resistance to artemisinin-based combination therapies","volume":"69","author":"Ward","year":"2022","journal-title":"Curr Opin Microbiol"},{"key":"2026061615214341300_jiag074-B23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1473-3099(15)00487-9","article-title":"Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study","volume":"16","author":"Amaratunga","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2026061615214341300_jiag074-B24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1473-3099(25)00407-4","article-title":"Efficacies of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6 months to 10 years in Uganda: a randomised, open-label, phase 4 clinical trial","volume":"26","author":"Kamya","year":"2026","journal-title":"Lancet Infect Dis"},{"key":"2026061615214341300_jiag074-B25","doi-asserted-by":"crossref","first-page":"e1001788","DOI":"10.1371\/journal.pmed.1001788","article-title":"Ultra-sensitive detection of Plasmodium falciparum by amplification of multi-copy subtelomeric targets","volume":"12","author":"Hofmann","year":"2015","journal-title":"PLoS Med"},{"key":"2026061615214341300_jiag074-B26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12936-025-05441-3","article-title":"Performance of molecular inversion probe DR23K and Paragon MAD(4)HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance","volume":"24","author":"Katairo","year":"2025","journal-title":"Malar J"},{"key":"2026061615214341300_jiag074-B27","doi-asserted-by":"crossref","first-page":"10737","DOI":"10.1038\/s41598-025-94716-5","article-title":"Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health","volume":"15","author":"Aranda-D\u00edaz","year":"2025","journal-title":"Sci Rep"},{"key":"2026061615214341300_jiag074-B28","author":"Gerlovina"},{"key":"2026061615214341300_jiag074-B29","doi-asserted-by":"crossref","first-page":"e00303-17","DOI":"10.1128\/mBio.00303-17","article-title":"A variant PfCRT isoform can contribute to plasmodium falciparum resistance to the first-line partner drug piperaquine","volume":"8","author":"Dhingra","year":"2017","journal-title":"mBio"},{"key":"2026061615214341300_jiag074-B30","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1038\/s41467-018-05652-0","article-title":"Emerging Southeast Asian PfCRT mutations confer plasmodium falciparum resistance to the first-line antimalarial piperaquine","volume":"9","author":"Ross","year":"2018","journal-title":"Nat Commun"},{"key":"2026061615214341300_jiag074-B31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1473-3099(16)30409-1","article-title":"Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study","volume":"17","author":"Amato","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2026061615214341300_jiag074-B32","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1473-3099(16)30415-7","article-title":"A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study","volume":"17","author":"Witkowski","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2026061615214341300_jiag074-B33","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1016\/S0140-6736(15)00310-4","article-title":"Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin-piperaquine versus intermittent preventive treatment with sulfadoxine-pyrimethamine for the control of malaria during pregnancy in western Kenya: an open-label, three-group, randomised controlled superiority trial","volume":"386","author":"Desai","year":"2015","journal-title":"Lancet"},{"key":"2026061615214341300_jiag074-B34","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMoa1509150","article-title":"Dihydroartemisinin-piperaquine for the prevention of malaria in pregnancy","volume":"374","author":"Kakuru","year":"2016","journal-title":"N Engl J Med"},{"key":"2026061615214341300_jiag074-B35","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/cpt.2273","article-title":"Effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaqunine against Malaria in pregnancy in Tanzania: a randomized controlled trial","volume":"110","author":"Mlugu","year":"2021","journal-title":"Clin Pharmacol Ther"},{"key":"2026061615214341300_jiag074-B36","doi-asserted-by":"crossref","first-page":"103202","DOI":"10.1016\/j.eclinm.2025.103202","article-title":"Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysis","volume":"83","author":"Roh","year":"2025","journal-title":"EClinicalMedicine"},{"key":"2026061615214341300_jiag074-B37","doi-asserted-by":"crossref","first-page":"e1001689","DOI":"10.1371\/journal.pmed.1001689","article-title":"Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial","volume":"11","author":"Bigira","year":"2014","journal-title":"PLoS Med"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiag074\/66866803\/jiag074.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/233\/6\/1110\/66866803\/jiag074.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/233\/6\/1110\/66866803\/jiag074.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:21:52Z","timestamp":1781637712000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/233\/6\/1110\/8475589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,2,13]]},"published-print":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiag074","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6,15]]},"published":{"date-parts":[[2026,2,13]]}}}