{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:17:39Z","timestamp":1792167459909,"version":"4.4.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100011880","name":"ARES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Group B Streptococcus (GBS) is a commensal vaginal bacterium that can lead to adverse maternal and neonatal outcomes. In low or middle-income countries, few data are available regarding the immune-inflammatory response in GBS-colonized pregnant mothers and its association with the risk of neonatal invasive disease. In this investigation, we implement a prospective study on a cohort of mother\u2013newborn dyads in Morocco to assess the cytokine profile in GBS-colonized-mothers whose newborns have invasive GBS disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pregnant women between 35 and 40 weeks of gestation were screened for vaginal colonization by GBS and followed up until delivery. A panel of inflammatory cytokines was quantified by Luminex multiplex assays and by ELISA in maternal and cord blood, as well as in supernatants after stimulation of pathogen recognition receptors. GBS-colonized-mothers were clustered according to clinical and inflammation markers and to their newborn's infection status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GBS-colonized-mothers whose newborns developed invasive GBS disease exhibited significantly lower IL-1\u03b2, IL-4, and IL-17A production compared with GBS-colonized-mothers with healthy newborns. Similar results were obtained following ex vivo stimulation of peripheral blood cells by TLR4 and TLR1\/2 ligands. The level of circulating maternal IL-17A had a higher significant predictive value for GBS transmission leading to invasive neonatal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that GBS-colonized-mothers may exhibit a greater cytokine inflammatory response compared with noncolonized-mothers. Regarding mother\u2013newborn dyads, maternal IL-17A, a key mediator of antibacterial defense, emerges as a significant prognostic biomarker for assessing the risk of GBS transmission and the development of neonatal GBS invasive disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag092","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:41:44Z","timestamp":1770468104000},"page":"888-898","source":"Crossref","is-referenced-by-count":2,"title":["Inflammatory Cytokine Profile in Pregnant Women Colonized With Group B Streptococcus Reveals IL-17a as a Potential Biomarker to Identify at-risk Newborns"],"prefix":"10.1093","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5704-7077","authenticated-orcid":false,"given":"Narjis","family":"Amar","sequence":"first","affiliation":[{"name":"Laboratory of Biology and Health, Research Center of Biotechnology and Health, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca , Casablanca ,","place":["Morocco"]},{"name":"Laboratory of Pediatric Research, Inflammation Unit, Faculty of Medicine, and ULB Center for Immunology, Universit\u00e9 Libre de Bruxelles (ULB) , Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0819-4871","authenticated-orcid":false,"given":"Azeddine","family":"Chakroun","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Health, Research Center of Biotechnology and Health, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca , Casablanca ,","place":["Morocco"]},{"name":"Laboratory of Pediatric Research, Inflammation Unit, Faculty of Medicine, and ULB Center for Immunology, Universit\u00e9 Libre de Bruxelles (ULB) , Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9898-0771","authenticated-orcid":false,"given":"Hanane","family":"Ben-Taleb","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Health, Research Center of Biotechnology and Health, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca , Casablanca ,","place":["Morocco"]},{"name":"Laboratory of Pediatric Research, Inflammation Unit, Faculty of Medicine, and ULB Center for Immunology, Universit\u00e9 Libre de Bruxelles (ULB) , Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5460-5270","authenticated-orcid":false,"given":"Hind","family":"Sebbah","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatric Research, Inflammation Unit, Faculty of Medicine, and ULB Center for Immunology, Universit\u00e9 Libre de Bruxelles (ULB) , Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1461-9010","authenticated-orcid":false,"given":"Amine","family":"Lamrissi","sequence":"additional","affiliation":[{"name":"Gynecology Obstetric Department, Children's Hospital A. Harouchi, CHU Ibn Rochd, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca , Casablanca ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5030-4983","authenticated-orcid":false,"given":"Amal","family":"Badre","sequence":"additional","affiliation":[{"name":"Neonatal Reanimation Department (P4), Children's Hospital A. Harouchi, CHU Ibn Rochd, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca , Casablanca ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2022-6811","authenticated-orcid":false,"given":"Norddine","family":"Habti","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, Genetics and Cell Engineering\u2014Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca , Casablanca ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-3228","authenticated-orcid":false,"given":"Hanane","family":"Salih-Alj","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Health, Research Center of Biotechnology and Health, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca , Casablanca 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