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In this phase 1 nonrandomized study, 6 individuals with virally suppressed HIV received a single dose of pembrolizumab to assess its safety and effects on immune, virologic, and central nervous system parameters. Over 12 months, 29 adverse events occurred, all grade 1 or 2, with no serious events. HIV immune responses and viral loads were unchanged, although transient CSF viral increases occurred in 2 participants. 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