{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:12:56Z","timestamp":1788369176822,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000030","name":"US Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["IP16-004"],"award-info":[{"award-number":["IP16-004"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["T32 ES010957"],"award-info":[{"award-number":["T32 ES010957"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020392","name":"Open Philanthropy\/Good Ventures Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["U01A1144673"],"award-info":[{"award-number":["U01A1144673"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children\u2019s Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MOM2Child","award":["R01HD109915"],"award-info":[{"award-number":["R01HD109915"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mitigating the underlying causes of differential immunity from rotavirus infection and vaccination requires a comprehensive understanding of rotavirus natural history and immune response. A US-based birth cohort provides a unique opportunity to longitudinally examine rotavirus immune response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum was collected from children at birth (cord blood), 6 weeks, and 6, 12, 18, and 24 months of age. Maternally-derived rotavirus-specific IgG (birth samples) and rotavirus-specific IgA and IgG (6-week through 24-month samples) were measured via enzyme immunoassay. Stool samples were collected weekly and during episodes of acute gastroenteritis to identify rotavirus infections. Serum samples prior to and after infection or vaccination were compared to assess their impact on IgA geometric mean titers (GMT). A generalized estimating equation was fit to identify predictors of IgA GMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median change in IgA GMT from vaccination comparing 6-week and 6-month samples was 38.4 U\/mL (IQR 4.4\u2013138.1). The change in IgA following infection varied widely (median = 64.5 [IQR 2.0\u2013192.9]) with preinfection and postinfection GMTs of 35.7 U\/mL (95% CI: 21.4\u201359.6) and 102.6 U\/mL (95% CI: 41.1\u2013256.0), respectively. In adjusted analyses, IgA GMT was higher when mother and\/or child was a secretor (ratio of means [RoM] = 1.3, 95% CI: 1.1\u20131.4) compared with nonsecretor mother\u2013child pairs. Being fully vaccinated was more strongly associated with IgA GMT in the first (RoM = 1.9, 95% CI: 1.7\u20132.0) compared with the second year of life (RoM = 1.3, 95% CI: 1.0\u20131.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This longitudinal assessment of rotavirus-specific immune response contributes to our understanding of multifactorial drivers of rotavirus immunity in a postvaccine setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag141","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:51:16Z","timestamp":1772283076000},"page":"e290-e301","source":"Crossref","is-referenced-by-count":0,"title":["Rotavirus-Specific IgA and IgG Patterns During the First 2 Years of Life in the PREVAIL Birth Cohort"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7872-316X","authenticated-orcid":false,"given":"Julia M","family":"Baker","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7505-4773","authenticated-orcid":false,"given":"Slavica","family":"Mijatovic-Rustempasic","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-4970","authenticated-orcid":false,"given":"Mary C","family":"Casey-Moore","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon","family":"White","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire P","family":"Mattison","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]},{"name":"Cherokee Nation Assurance , Tulsa, Oklahoma ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-5826","authenticated-orcid":false,"given":"Rachel M","family":"Burke","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3715-5842","authenticated-orcid":false,"given":"Shannon C","family":"Conrey","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]},{"name":"Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardythe L","family":"Morrow","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]},{"name":"Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-911X","authenticated-orcid":false,"given":"Daniel C","family":"Payne","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashi","family":"Gautam","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh D","family":"Parashar","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline E","family":"Tate","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, US Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Allen","family":"Staat","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M","family":"McNeal","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio ,","place":["USA"]},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"2026090212184926500_jiag141-B1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/14760584.2018.1489724","article-title":"A decade of experience with rotavirus vaccination in the United States\u2014vaccine uptake, effectiveness, and impact","volume":"17","author":"Pindyck","year":"2018","journal-title":"Expert Rev Vaccines"},{"key":"2026090212184926500_jiag141-B2","author":"World Health Organization"},{"key":"2026090212184926500_jiag141-B3","doi-asserted-by":"crossref","first-page":"S792","DOI":"10.1093\/infdis\/jiab399","article-title":"Global experience with rotavirus vaccines","volume":"224","author":"Burke","year":"2021","journal-title":"J Infect Dis"},{"key":"2026090212184926500_jiag141-B4","doi-asserted-by":"crossref","first-page":"e1195","DOI":"10.1016\/S2214-109X(20)30262-X","article-title":"Real-world 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