{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:55:27Z","timestamp":1793084127068,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"name":"US Government"},{"DOI":"10.13039\/100009210","name":"Food and Drug Administration","doi-asserted-by":"publisher","award":["75F40119C10128"],"award-info":[{"award-number":["75F40119C10128"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To date, 18 Marburg virus disease (MVD) outbreaks have been reported, most recently in Tanzania and Ethiopia. From 1998 to 2000, a large MVD outbreak in Watsa\/Durba region, Democratic Republic of the Congo (DRC), resulted in 154 cases and 128 deaths. Given the public health risks posed by MARV, the lack of approved vaccines and therapeutics, and unpredictability of future outbreaks, this study aimed to assess the anti-MARV seroprevalence in Watsa\/Durba.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Samples collected in May 2023 (n = 313) included known MVD survivors (n = 5), close contacts (n = 22), and other residents (n = 286). A multiplexed immunoassay was used to assess seroreactivity to MARV and other pan-filovirus targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the Watsa\/Durba cohort, 4.5% and 1.6% were seroreactive to MARV glycoprotein (GP) and VP40, including only 1 known MVD survivor. No significant associations were found between MARV seroreactivity and risk factors: travel to Uganda, receiving injections, or employment as a gold miner. Of those 14 MARV GP-reactive individuals, 85.7% were cross-reactive to other filoviral targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This detected seroprevalence among individuals with no known exposure history may indicate continued exposure to MARV or MARV-like antigens 25 years after the conclusion of the outbreak; cross-reactivity to pan-filovirus targets further suggest the potential for undetected cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag155","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:54:06Z","timestamp":1773330846000},"page":"e724-e733","source":"Crossref","is-referenced-by-count":6,"title":["Detection of Marburg Virus Antibodies 25 Years After Outbreak in Watsa, Democratic Republic of the Congo"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-605X","authenticated-orcid":false,"given":"Sydney","family":"Merritt","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick K","family":"Mukadi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Global Health, Institut National de Recherche Biom\u00e9dicale (INRB) , Kinshasa ,","place":["Democratic Republic of the Congo"]},{"name":"Department of Medical Biology, University Hospital of Kinshasa, University of Kinshasa , Kinshasa ,","place":["Democratic Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Kompany","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Global Health, Institut National de Recherche Biom\u00e9dicale (INRB) , Kinshasa ,","place":["Democratic Republic of the Congo"]},{"name":"Department of Medical Biology, University Hospital of Kinshasa, University of Kinshasa , Kinshasa ,","place":["Democratic Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3892-2655","authenticated-orcid":false,"given":"Megan","family":"Halbrook","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamy","family":"Musene","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5981-7317","authenticated-orcid":false,"given":"Skylar A","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Beya","sequence":"additional","affiliation":[{"name":"Kinshasa School of Public Health (KSPH), University of Kinshasa , Kinshasa ,","place":["Democratic Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merly","family":"Tambu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Global Health, Institut National de Recherche Biom\u00e9dicale (INRB) , Kinshasa ,","place":["Democratic Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri Ann S","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa , Honolulu, Hawaii ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Jacques","family":"Muyembe-Tamfum","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Global Health, Institut National de Recherche Biom\u00e9dicale (INRB) , Kinshasa ,","place":["Democratic Republic of the Congo"]},{"name":"Department of Medical Biology, University Hospital of Kinshasa, University of Kinshasa , Kinshasa ,","place":["Democratic Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-5147","authenticated-orcid":false,"given":"Didine K","family":"Kaba","sequence":"additional","affiliation":[{"name":"Kinshasa School of Public Health (KSPH), University of Kinshasa , Kinshasa ,","place":["Democratic Republic of the Congo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-203X","authenticated-orcid":false,"given":"Axel T","family":"Lehrer","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. 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