{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:00:41Z","timestamp":1790190041417,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["566792"],"award-info":[{"award-number":["566792"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["OPP1116833"],"award-info":[{"award-number":["OPP1116833"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"Victorian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Correlates of protection for pneumococcal carriage, a precursor for invasive pneumococcal disease, are not well-defined. The relationship between memory B cells (Bmem) with carriage remains unclear. We assessed serotype-specific Bmem, IgG, and opsonophagocytic (OPA) responses following different infant schedules of 10-valent pneumococcal conjugate vaccine (PCV10, Synflorix) and their association with pneumococcal carriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed secondary outcome data from a phase II\/III randomized controlled trial in Vietnam (trial registration NCT01953510). Infants received PCV10 in a 3 + 1 (2\u20133\u20134\u20139 months), 3 + 0 (2\u20133\u20134 months), or 2 + 1 (2\u20134\u20139.5 months) schedule. Serotype-specific Bmem, IgG, and OPA were measured at 10 months (all) and 18 months (Bmem and IgG only). Carriage was assessed from nasopharyngeal swabs at 12\u201318\u201324 months with additional carriage episodes identified by seroincidence. Associations between immunological parameters at 10 months and subsequent carriage were evaluated using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 10 months, Bmem levels were similar across vaccine arms, but IgG and OPA were higher in the 3 + 1\/2 + 1 than 3 + 0 arm. At 18 months, Bmem and IgG waned for most serotypes in all vaccine arms. There were minimal associations between the immunological parameters and subsequent carriage. Only IgG was negatively associated with serotype 19A carriage, when defined as carriage and\/or seroincidence \u22652-fold (odds ratio: 0.31, 95% CI: .10\u2013.94, P = .038), and carriage and\/or seroincidence of any increase (odds ratio: 0.13, 95% CI: .04\u2013.40, P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found no substantive evidence linking Bmem, IgG, and OPA with pneumococcal carriage. Larger studies are needed to identify associations between different immunological parameters and carriage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag157","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:43:43Z","timestamp":1773146623000},"page":"e702-e713","source":"Crossref","is-referenced-by-count":0,"title":["Serotype-specific Immunity and Association With Pneumococcal Carriage Following 3+1, 3+0, and 2+1 Schedules of 10-valent Pneumococcal Conjugate Vaccine"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-1376","authenticated-orcid":false,"given":"Darren Suryawijaya","family":"Ong","sequence":"first","affiliation":[{"name":"Infection, Immunity and Global Health, Murdoch Children's Research Institute , Parkville, VIC ,","place":["Australia"]},{"name":"Department of Paediatrics, The University of Melbourne , Parkville, VIC 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,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0599-8645","authenticated-orcid":false,"given":"Cattram Duong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Infection, Immunity and Global Health, Murdoch Children's Research Institute , Parkville, VIC ,","place":["Australia"]},{"name":"Department of Paediatrics, The University of Melbourne , Parkville, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5056-7285","authenticated-orcid":false,"given":"Thanh V","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pasteur Institute of Ho Chi Minh City , Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Thi Trang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pasteur Institute of Ho Chi Minh City , Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Balloch","sequence":"additional","affiliation":[{"name":"Infection, Immunity and Global Health, Murdoch Children's Research Institute , Parkville, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Ann","family":"Higgins","sequence":"additional","affiliation":[{"name":"Infection, Immunity and Global Health, Murdoch Children's Research Institute , Parkville, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda Daniela","family":"Ortika","sequence":"additional","affiliation":[{"name":"Infection, Immunity and Global Health, Murdoch Children's Research Institute , Parkville, VIC 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Thi","family":"Hoan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pasteur Institute of Ho Chi Minh City , Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Bun","family":"Cheung","sequence":"additional","affiliation":[{"name":"Centre for Quantitative Medicine, Duke-NUS Medical School ,","place":["Singapore"]},{"name":"Tampere Centre for Maternal, Child and Adolescent Health Research, Tampere University Arvo Ylp\u00f6n Katu 34 , Tampere ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Smith-Vaughan","sequence":"additional","affiliation":[{"name":"Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University , Casuarina, NT 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