{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:13:44Z","timestamp":1788369224254,"version":"build-2803163510"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Xinjiang Talent Development Fund","award":["XJRC-2025-KJ-PY-KJLJ-111"],"award-info":[{"award-number":["XJRC-2025-KJ-PY-KJLJ-111"]}]},{"name":"Key Program of Xinjiang Natural Science Foundation","award":["2022D01D59"],"award-info":[{"award-number":["2022D01D59"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xinjiang Regional Collaborative Innovation Program","award":["2024E02040"],"award-info":[{"award-number":["2024E02040"]}]},{"DOI":"10.13039\/100009110","name":"Xinjiang Natural Science Foundation","doi-asserted-by":"publisher","award":["2025D01C165"],"award-info":[{"award-number":["2025D01C165"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of High Incidence Disease Research"},{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009122","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2023C06"],"award-info":[{"award-number":["2023C06"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alveolar echinococcosis (AE), caused by Echinococcus multilocularis (E. multilocularis), exhibits tumor-like, invasive growth in the liver. Unlike cystic echinococcosis, AE lesions are bordered by loose fibrosis, not a dense capsule. How the parasite weakens this host fibrotic response remians unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified functional miRNAs in parasite-derived exosomes via small RNA sequencing and multi-step screening, validated them using bioinformatics, luciferase assays, and in vitro studies in hepatic stellate cell studies (HSCs) and inhibited the target in vivo with AAV6-delivered TuD RNA in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exosomal emu-miR-745-3p from E. multilocularis targets DPP4 in HSCs, suppressing their activation and reducing fibrotic markers (\u03b1-SMA, COL1A1, TIMP1). In vivo inhibition of this miRNA increased perilesional fibrosis and capsule thickness, and decreased parasite burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>E. multilocularis employs exosomal emu-miR-745-3p to attenuate host fibrotic encapsulation, facilitating invasive growth. The emu-miR-745-3p\/DPP4 axis is a critical determinant of AE pathology and a potential target for novel anti-fibrotic therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag215","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:20:53Z","timestamp":1776079253000},"page":"297-309","source":"Crossref","is-referenced-by-count":0,"title":["Tearing Down the Wall: emu-miR-745-3p in\n                    <i>Echinococcus multilocularis<\/i>\n                    Exosomes Attenuates Host Liver Fibrosis to Permit Invasive Lesion Development"],"prefix":"10.1093","volume":"234","author":[{"given":"Ning","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University , Urumqi, Xinjiang ,","place":["PR China"]},{"name":"Key Laboratory of 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