{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:12:54Z","timestamp":1788369174843,"version":"build-2803163510"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003107","name":"German Federal Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032527","name":"Bernhard-Nocht-Institute for Tropical Medicine","doi-asserted-by":"crossref","award":["I1-2517WHO005"],"award-info":[{"award-number":["I1-2517WHO005"]}],"id":[{"id":"10.13039\/100032527","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Global Health Protection Program","award":["ZMV I1-2517GHP-704"],"award-info":[{"award-number":["ZMV I1-2517GHP-704"]}]},{"name":"Global Health Protection Program","award":["ZMVI1-2519GHP704"],"award-info":[{"award-number":["ZMVI1-2519GHP704"]}]},{"name":"Global Health Protection Program","award":["ZMI1-2521GHP921"],"award-info":[{"award-number":["ZMI1-2521GHP921"]}]},{"name":"Global Health Protection Program","award":["ZMI5-2523GHP006"],"award-info":[{"award-number":["ZMI5-2523GHP006"]}]},{"name":"Global Health Protection Program","award":["ZMI5-2523GHP008"],"award-info":[{"award-number":["ZMI5-2523GHP008"]}]},{"DOI":"10.13039\/100010661","name":"H2020","doi-asserted-by":"publisher","award":["871029-EVA-GLOBAL"],"award-info":[{"award-number":["871029-EVA-GLOBAL"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lassa fever is endemic in Guinea, with high seroprevalence in the forest region. However, clinical cases have been only anecdotally reported. In August 2022, a nosocomial outbreak occurred at a private clinic in the capital, Conakry, an area previously considered low risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Suspected cases were confirmed by real-time reverse-transcription polymerase chain reaction within 24 hours. Viremia was monitored during hospitalization, and whole-genome sequencing was performed in-country within 13 days of outbreak detection. Outbreak investigation involved rodent testing in the home village of the suspected primary case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six cases were laboratory-confirmed, 5 of which were healthcare workers of the clinic. The case fatality rate was 16.7%. Viral RNA remained detectable in blood of survivors for a median of 26 days (interquartile range, 24\u201341 days) post\u2013disease onset. Epidemiological investigations identified a suspected primary case, who had died of a febrile disease compatible with Lassa fever, had contact with all secondary cases, and had a travel history from Kissidougou area. Three near-complete and 1 partial Lassa virus genomes were recovered from the secondary cases, which phylogenetically clustered with genomes from central Guinea. Consistent with a common transmission source, the 4 genomes were almost identical. Rodent testing revealed a new reservoir area in eastern-central Guinea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This outbreak highlights the vulnerability of healthcare settings in low-prevalence areas of West Africa to nosocomial Lassa virus transmission due to human mobility. Facilitated by capacity-building programs for viral hemorrhagic fevers, rapid diagnosis, genomic analysis, and ecological assessment enabled an efficient outbreak response and control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag229","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:27:39Z","timestamp":1776770859000},"page":"189-197","source":"Crossref","is-referenced-by-count":1,"title":["Nosocomial Outbreak of Lassa Fever in Conakry, Guinea, 2022"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1570-4624","authenticated-orcid":false,"given":"Giuditta","family":"Annibaldis","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine Department of Virology, , Hamburg ,","place":["Germany"]},{"name":"German Center for Infection Research, partner site Hamburg-L\u00fcbeck-Borstel-Riems , Hamburg 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