{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:54:24Z","timestamp":1781661264223,"version":"3.54.5"},"reference-count":50,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Independent Research Fund Denmark- DFF","award":["0134-00123B"],"award-info":[{"award-number":["0134-00123B"]}]},{"name":"Danish International Development Agency-Danida"},{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Africa Research Excellence Fund"},{"DOI":"10.13039\/501100021343","name":"AREF","doi-asserted-by":"publisher","award":["AREF-325-PART-F-C0929"],"award-info":[{"award-number":["AREF-325-PART-F-C0929"]}],"id":[{"id":"10.13039\/501100021343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2024\/05344-4"],"award-info":[{"award-number":["2024\/05344-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DANIDA-sponsored Building Stronger Universities initiative","award":["BSU3-UG"],"award-info":[{"award-number":["BSU3-UG"]}]},{"name":"SumayaVac-1","award":["SUM-101"],"award-info":[{"award-number":["SUM-101"]}]},{"name":"Sumaya Biotech GmbH & Co"},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"EDCTP","doi-asserted-by":"publisher","award":["RIA2018SV-2311"],"award-info":[{"award-number":["RIA2018SV-2311"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>IgG-mediated effector functions are modulated by the antibody Fc-region glycan composition, and the absence of core fucose is a strong modifier of NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC). Most plasma IgG is fully Fc-fucosylated, but antigens displayed on host-derived membranes can selectively induce Fc-afucosylated IgG. These antigens include alloantigens, enveloped virus surface proteins, and PfEMP1, a malaria parasite protein expressed on the surface of Plasmodium falciparum-infected erythrocytes (IEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We determined levels and Fc-fucosylation of IgG specific for several P. falciparum antigens in plasma from children naturally exposed to P. falciparum and from vaccinated adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IgG specific for PfEMP1 (known to be exposed on the IE surface) and PfGARP, a putative IE surface antigen, were markedly Fc-afucosylated, whereas IgG specific for antigens on parasite membranes (merozoites, gametocytes\/gametes, and sporozoites) were fully Fc-fucosylated in most of the children naturally exposed to P. falciparum studied here. Immunization of adults with recombinant proteins (MSP1, Pfs230, and CSP) also consistently induced fully Fc-fucosylated IgG. Children with Fc-afucosylated PfGARP-specific IgG had reduced risk of carrying P. falciparum parasites, independent of levels of PfGARP-specific IgG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results reinforce the hypothesis that Fc-afucosylation of antigen-specific IgG requires exposure of the antigen on a host membrane (context) and is a function of antigen exposure. Host-specific factors appear to play a minor role in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag296","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:02:11Z","timestamp":1781010131000},"source":"Crossref","is-referenced-by-count":0,"title":["Fc-fucosylation of\n                    <i>Plasmodium falciparum<\/i>\n                    -specific IgG Varies With Antigen and Immunization"],"prefix":"10.1093","author":[{"given":"Frederica Dedo","family":"Partey","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana , Accra ,","place":["Ghana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-6782","authenticated-orcid":false,"given":"Maria Ines","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-2491","authenticated-orcid":false,"given":"Zakaria","family":"Seidu","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana , Accra ,","place":["Ghana"]},{"name":"West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, University of Ghana , Accra ,","place":["Ghana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5104-3946","authenticated-orcid":false,"given":"Alfred B","family":"Tiono","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Action en Sant\u00e9 (GRAS) , Ouagadougou ,","place":["Burkina Faso"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-9497","authenticated-orcid":false,"given":"Richard","family":"Thomson-Luque","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Parasitology, Heidelberg University, Medical Faculty, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]},{"name":"Sumaya-Biotech GmbH & Co. KG , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0814-4995","authenticated-orcid":false,"given":"Manfred","family":"Wuhrer","sequence":"additional","affiliation":[{"name":"Center for Proteomics and Metabolomics, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-5901","authenticated-orcid":false,"given":"Mads Delbo","family":"Larsen","sequence":"additional","affiliation":[{"name":"Immunoglobulin Research Laboratory, Sanquin Research , Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-003X","authenticated-orcid":false,"given":"Gestur","family":"Vidarsson","sequence":"additional","affiliation":[{"name":"Immunoglobulin Research Laboratory, Sanquin Research , Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kurtis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Brown University Medical School , Providence, Rhode Island ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Blackman","sequence":"additional","affiliation":[{"name":"Malaria Biochemistry Laboratory, The Francis Crick Institute , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lanzer","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Parasitology, Heidelberg University, Medical Faculty, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-1392","authenticated-orcid":false,"given":"Michael","family":"Theisen","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department for Congenital Disorders, Statens Serum Institut (SSI) , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F","family":"Ofori","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana , Accra ,","place":["Ghana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-4927","authenticated-orcid":false,"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Infectious Diseases, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-0248","authenticated-orcid":false,"given":"Mary","family":"Lopez-Perez","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine and Parasitology, 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