{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:45:03Z","timestamp":1792025103957,"version":"4.4.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mevox Ltd"},{"DOI":"10.13039\/100024043","name":"Pediatric Scientist Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12-HD000850"],"award-info":[{"award-number":["K12-HD000850"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-AI052071"],"award-info":[{"award-number":["T32-AI052071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bauernschmidt Committee of the Eudowood Board"},{"DOI":"10.13039\/100012304","name":"Johns Hopkins School of Medicine","doi-asserted-by":"publisher","award":["T32 OD011089"],"award-info":[{"award-number":["T32 OD011089"]}],"id":[{"id":"10.13039\/100012304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012304","name":"Johns Hopkins School of Medicine","doi-asserted-by":"publisher","award":["R01 AI182066"],"award-info":[{"award-number":["R01 AI182066"]}],"id":[{"id":"10.13039\/100012304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012304","name":"Johns Hopkins School of Medicine","doi-asserted-by":"publisher","award":["R01 AI153140"],"award-info":[{"award-number":["R01 AI153140"]}],"id":[{"id":"10.13039\/100012304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016820","name":"Vaccine Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016820","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Different measles vaccine platforms protect against clinical disease, but characteristics of the resulting humoral responses remain incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, a phage display immunoprecipitation sequencing technology, VirScan, was employed to evaluate measles viral epitope coverage by antibodies following wild-type (WT) measles virus (MeV) infection of rhesus macaques, or vaccination with a live attenuated MeV vaccine (LAMV), the triple measles-mumps-rubella vaccine (MMR), or a novel recombinant MeV hemagglutinin protein\u2013based vaccine (rMeVH). Vaccinated animals were also challenged with WT MeV to measure antibody epitope reactivity during a recall.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results demonstrate that WT MeV infection elicited a broader epitope reactivity profile than LAMV-containing vaccines. Also, rMeVH vaccination not only resulted in a narrow H protein\u2013specific antibody profile, but epitopes recognized were distinct from LAMV-vaccinated or WT-challenged animals. All vaccine groups expanded the breadth of MeV-specific antibody repertoires following WT MeV challenge. In addition, MeV-specific VarScore, a measure of overall antigen binding, was positively correlated with IgG titer assessed by enzyme-linked immunosorbent assay, as well as antibody avidity and neutralizing titers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results demonstrate the distinct effects of vaccination platforms on the breadth and fine specificity of anti-measles\u2013induced humoral responses, and the utility of VirScan for comprehensively assessing antibody epitope targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiag309","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:30:28Z","timestamp":1781613028000},"page":"e765-e776","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Humoral Response Development to Measles Virus Across Vaccine Platforms"],"prefix":"10.1093","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2025-6375","authenticated-orcid":false,"given":"Andy K P","family":"Chan","sequence":"first","affiliation":[{"name":"W.Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]},{"name":"Graduate Program in Immunology, Johns Hopkins University School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-3132","authenticated-orcid":false,"given":"Jacqueline K","family":"Brockhurst","sequence":"additional","affiliation":[{"name":"W.Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0079-7381","authenticated-orcid":false,"given":"Liting","family":"Liu","sequence":"additional","affiliation":[{"name":"W.Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shristi","family":"Ghimire","sequence":"additional","affiliation":[{"name":"W.Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Baumgarth","sequence":"additional","affiliation":[{"name":"W.Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]},{"name":"Graduate Program in Immunology, Johns Hopkins University School of Medicine , Baltimore, Maryland ,","place":["USA"]},{"name":"Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E","family":"Griffin","sequence":"additional","affiliation":[{"name":"W.Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"2026101419590977000_jiag309-B1","author":"World Health Organization"},{"key":"2026101419590977000_jiag309-B2","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/S0140-6736(24)00850-X","article-title":"Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization","volume":"403","author":"Shattock","year":"2024","journal-title":"Lancet"},{"key":"2026101419590977000_jiag309-B3","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2500\/aap.2021.42.210065","article-title":"The global burden of vaccine-preventable infectious diseases in children less than 5 years of age: implications for COVID-19 vaccination. 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